Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis

Zhan L, Lei Zhan, Wang W, Wenyan Wang, Yu Zhang, Zhang Y, Enxue Song, Song E, Fan Y, Yijun Fan, Wei B, Bing Wei
Biochimie · 2016 · vol. 123 , pp. 130–137 · doi:10.1016/j.biochi.2016.01.006 · PMID:26898675 · W2281183452
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This paper explores hypoxia-inducible factor-1alpha (HIF-1α) as a potential therapeutic target for endometriosis, based on its role in disease pathology.

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Abstract

Endometriosis is a common gynecologic disease defined as the presence of ectopic endometrial tissues on the ovaries and pelvic peritoneum, and it is a significant cause of pelvic pain, dysmenorrhea and infertility of women in their reproductive age. However, the etiology of endometriosis remains obscure. In recent years, a growing body of evidence validated that hypoxia developed a close relationship with endometriosis and the expression of hypoxia-inducible factor-1alpha (HIF-1α) was increased significantly in the development of endometriosis. Furthermore, inhibiting the expression of HIF-1α contributed to suppress endometriosis progression, suggesting HIF-1α plays a critical function in endometriosis. Nevertheless, the mechanisms by which HIF-1α associates with endometriosis are still undefined. In this brief review, we had a general understanding of HIF-1α firstly, and then we tried to sum up the collective knowledge of HIF-1α in endometriosis. Finally, we will discuss kinds of novel therapeutic approaches to endometriosis based on the functions of HIF-1α.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Adult Endometriosis Female Humans Hypoxia-Inducible Factor 1, alpha Subunit

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (33)

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License: CC0 · commercial use OK