Hypoxia-inducible factor-1alpha: A promising therapeutic target in endometriosis

Zhan L, Lei Zhan, Wang W, Wenyan Wang, Yu Zhang, Zhang Y, Enxue Song, Song E, Fan Y, Yijun Fan, Wei B, Bing Wei
Biochimie · 2016 · vol. 123 , pp. 130–137 · doi:10.1016/j.biochi.2016.01.006 · PMID:26898675 · W2281183452
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This paper explores hypoxia-inducible factor-1alpha (HIF-1α) as a potential therapeutic target for endometriosis, based on its role in disease pathology.

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Abstract

Endometriosis is a common gynecologic disease defined as the presence of ectopic endometrial tissues on the ovaries and pelvic peritoneum, and it is a significant cause of pelvic pain, dysmenorrhea and infertility of women in their reproductive age. However, the etiology of endometriosis remains obscure. In recent years, a growing body of evidence validated that hypoxia developed a close relationship with endometriosis and the expression of hypoxia-inducible factor-1alpha (HIF-1α) was increased significantly in the development of endometriosis. Furthermore, inhibiting the expression of HIF-1α contributed to suppress endometriosis progression, suggesting HIF-1α plays a critical function in endometriosis. Nevertheless, the mechanisms by which HIF-1α associates with endometriosis are still undefined. In this brief review, we had a general understanding of HIF-1α firstly, and then we tried to sum up the collective knowledge of HIF-1α in endometriosis. Finally, we will discuss kinds of novel therapeutic approaches to endometriosis based on the functions of HIF-1α.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Adult Adult Endometriosis Endometriosis Female Female Humans Humans Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (95)

Cited by (34)

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License: CC0 · commercial use OK