Wenshen Xiaozheng Tang suppresses the growth of endometriosis with an antiangiogenic effect

Z Z Zhang, Zhi‐Tong Zhang, Chanchan Hu, C P Hu, Weiwei Tang, W W Tang, Tao Gui, T Gui, Ruoning Qian, R Y Qian, Yuxin Xing, Y X Xing, P Cao, Peng Cao, Guiping Wan, G P Wan
Climacteric : the journal of the International Menopause Society · 2013 · vol. 16(6) , pp. 700–708 · doi:10.3109/13697137.2013.771331 · PMID:23394299 · W2081877488
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Wenshen Xiaozheng Tang treatment decreased endometriosis lesion size and inhibited cell proliferation, likely by reducing angiogenesis via decreased VEGF and HIF-1α expression.

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Abstract

OBJECTIVE: To evaluate the effect of Wenshen Xiaozhng Tang (WXT) on ectopic endometrial growth and on angiogenesis in endometrial implants in a rat model. METHODS: Sprague-Dawley rats with endometriotic implants were randomly treated with low-dose WXT, high-dose WXT, or vehicle (negative control) for 28 days. Cell proliferation and vascular density in the lesions were assessed by immunohistochemistry. The levels of VEGF in peritoneal fluid were determined by ELISA. The mRNA expression of HIF-1α and Flk-1 in the endometriotic lesions was evaluated by real-time PCR. RESULTS: WXT treatment significantly decreased the lesion size and inhibited cell proliferation in the endometriotic lesions. Lowered vascular density and reduced mRNA expression of HIF-1α in the endometriotic lesions, associated with decreased concentration of VEGF in peritoneal fluid, were also observed in WXT-treated rats. CONCLUSIONS: These results suggest that WXT could be effective to suppress the growth of endometriosis, partially through its antiangiogenic activity.

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Condition tags

endometriosis

MeSH descriptors

Angiogenesis Inhibitors Drugs, Chinese Herbal Endometriosis Angiogenesis Inhibitors Angiogenesis Inhibitors Animals Ascitic Fluid Ascitic Fluid Cell Proliferation Cell Proliferation Disease Models, Animal Drugs, Chinese Herbal Endometriosis Endometriosis Female Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Neovascularization, Pathologic Neovascularization, Pathologic Neovascularization, Pathologic

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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