Vascular endothelial growth factor genetic polymorphisms at +405C/G and -460 C/T and the association with advanced stages of endometriosis

Andrei Mihai Măluţan, Răzvan Ciortea, Ciprian Porumb, Radu Florin Mocan-Hognogi, Dan Mihu
In: Clinical and Experimental Obstetrics & Gynecology · 2018 · vol. 45(5) , pp. 725–730 · doi:10.12891/ceog4304.2018 · W3036347718
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This study found no significant association between VEGF +405 C/G and -460 C/T genetic polymorphisms and advanced endometriosis or VEGF serum levels.

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This paper investigated whether vascular endothelial growth factor (VEGF) genetic polymorphisms at +405C/G and -460C/T are associated with endometriosis, their relationship to VEGF serum levels, and their impact on endometriosis susceptibility, using allele, genotype, and haplotype frequencies assessed by PCR-RFLP. The authors reported no significant association between mutant allele presence and endometriosis, and found no statistically significant differences in VEGF serum levels by allele, genotype, or related variation. The paper concludes that these specific VEGF polymorphisms are not associated with advanced endometriosis and that VEGF serum levels did not significantly correlate with these genotypes. This paper is centrally about endometriosis—specifically testing VEGF +405C/G and -460C/T polymorphisms for association with advanced disease and circulating VEGF levels.

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Abstract

Purpose of investigation: Endometriosis is a common gynecologic disease, with a genetic component, a series of studies involving different vascular endothelial growth factor (VEGF) genetic variants in endometriosis pathogenesis. In this study, the authors aimed to describe the presence of VEGF genetic polymorphisms in relationship with endometriosis, to evaluate their relationship with VEGF serum levels, and to investigate its impact on endometriosis susceptibility. Materials and Methods: The authors studied the frequency of alleles, genotypes, and haplotypes of VEGF +405 C/G and -460 C/T genetic polymorphisms in patients with endometriosis, by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: This study did not find any significant relationship between the presence of mutant allele and endometriosis. Regarding VEGF serum levels and the presence of a different allele, there was also no statistically significant difference. Conclusion: This research shows that VEGF +405 C/G and -460 C/T genetic polymorphisms are not associated with advanced endometriosis, and VEGF serum levels did not correlate significantly in relationship with the presence of a different allele and/or genotypes, thus suggesting no involvement for this polymorphism in the pathogenesis of endometriosis.
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Abstract

Purpose of investigation: Endometriosis is a common gynecologic disease, with a genetic component, a series of studies involving different vascular endothelial growth factor (VEGF) genetic variants in endometriosis pathogenesis. In this study, the authors aimed to describe the presence of VEGF genetic polymorphisms in relationship with endometriosis, to evaluate their relationship with VEGF serum levels, and to investigate its impact on endometriosis susceptibility. Materials and Methods: The authors studied the frequency of alleles, genotypes, and haplotypes of VEGF +405 C/G and -460 C/T genetic polymorphisms in patients with endometriosis, by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: This study did not find any significant relationship between the presence of mutant allele and endometriosis. Regarding VEGF serum levels and the presence of a different allele, there was also no statistically significant difference. Conclusion: This research shows that VEGF +405 C/G and -460 C/T genetic polymorphisms are not associated with advanced endometriosis, and VEGF serum levels did not correlate significantly in relationship with the presence of a different allele and/or genotypes, thus suggesting no involvement for this polymorphism in the pathogenesis of endometriosis.

Keywords

- Endometriosis - Genetic polymorphism - Infertility - Angiogenesis

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endometriosis

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