Vascular Endothelial Growth Factor-A (VEGF-A) Single Nucleotide Polymorphisms and Endometriosis: Still a Controversial Issue:

Guido Bocci, Alessandro Fasciani, Paola Orlandi, Antonello Di Paolo, Mario Del Tacca, Romano Danesi
2009 · vol. 1(2) , pp. 94–101 · doi:10.5301/je.2009.3584 · W2260610674
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This review critically examines conflicting studies on associations between VEGF-A single nucleotide polymorphisms and the risk, pathogenesis, or stage of endometriosis.

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Abstract

Abstract\n\nEndometriosis is a chronic, multifactorial, polygenic gynecological disease. Endometrium has a high angiogenic potential and endometriotic lesions involve large areas with a rich blood supply. Angiogenesis is controlled by numerous inducers, including the vascular endothelial growth factor (VEGF) family. Endometrium undergoes cyclical growth and regression during the menstrual cycle, which depends on ovarian steroid levels and is a rich source of angiogenic growth factors, including VEGF-A. The VEGF-A gene is located on chromosome 6p21.3 and it is highly polymorphic with more than 20 different variants. This article critically reviews the published data concerning the relationships between some of the VEGF-A single nucleotide polymorphisms and the risk, pathogenesis and stage of endometriosis. Contrasting results have been published in the literature - probably due to the different ethnic background and the number of patients enrolled in clinical trials. However, the incre...

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endometriosis

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