[Association of single nucleotide polymorphisms in VEGF gene with the risk of endometriosis and adenomyosis].

Qing Liu, Yan Li, Jian Zhao, Rong-miao Zhou, Rong‐Miao Zhou, Na Wang, Dong-lan Sun, Dong‐Lan Sun, Ya-nan Duan, Yanan Duan, Shan Kang
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2009 · vol. 26(2) , pp. 165–9 · doi:10.3760/cma.j.issn.1003-9406.2009.02.010 · PMID:19350508 · W16192626
article OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

The VEGF -1154G/A polymorphism, but not the -460C/T polymorphism, was associated with an increased risk of endometriosis and adenomyosis, with the GG genotype conferring the highest risk.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The study investigated whether single nucleotide polymorphisms in the VEGF gene promoter (-460C/T and -1154G/A) are associated with susceptibility to endometriosis and adenomyosis by genotyping 344 endometriosis patients and 360 controls, and 174 adenomyosis patients and 199 controls using PCR-RFLP. No significant differences were found between either patient group and controls for VEGF -460C/T genotype or allele frequencies (all P>0.05). In contrast, VEGF -1154G/A showed significant differences in both conditions: the GG genotype was associated with higher risk compared with GA+AA (endometriosis OR=1.43, 95% CI 1.05–1.96; adenomyosis OR=1.95, 95% CI 1.26–3.03), and allele frequencies also differed (all P<0.05). The paper does not explicitly discuss limitations in the abstract; it is limited to the two promoter SNPs and the studied sample set. This paper is centrally about endometriosis and adenomyosis — specifically, it tests VEGF promoter -1154G/A and -460C/T polymorphisms for genetic risk association.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate the association of single nucleotide polymorphisms (SNPs) in VEGF gene with the risk of endometriosis and adenomyosis. METHODS: Genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 344 endometriosis patients, 174 adenomyosis patients, 360 frequency-matched control women of endometriosis and 199 frequency-matched control women of adenomyosis. RESULTS: No significant difference was found in allele frequencies and genotype distributions of the -460C/T polymorphism between patients (endometriosis and adenomyosis) and control women (all P value > 0.05). However, there were significant differences in genotype and allele distributions of the VEGF -1154G/A polymorphism between patients (endometriosis and adenomyosis) and control women (all P value < 0.05). The genotype frequencies of the VEGF -1154 AA, GA, and GG in endometriosis patients and control women were 1.7%, 28.8%, 69.5% and 5.8%, 32.8%, 61.4%, respectively; and the A and G allele frequencies in the two groups were 16.1%, 83.9% and 22.2%, 77.8%, respectively. The genotype frequencies of the VEGF -1154 AA, GA, and GG in adenomyosis patients and control women were 2.9%, 23.6%, 73.6% and 7.0%, 34.2%, 58.8%, respectively; and the A and G allele frequencies in the two groups were 14.7%, 85.3% and 24.1%, 75.9% respectively. Compared with GA+ AA genotype, GG genotypes could significantly increase the risk of endometriosis (OR:1.43,95%CI:1.05-1.96) and adenomyosis (OR:1.95,95%CI:1.26-3.03). CONCLUSION: The VEGF -1154G/A polymorphism was associated with susceptibility to endometriosis and adenomyosis, and the GG genotype could significantly increase the risk of developing endometriosis and adenomyosis. However, the VEGF -460C/T polymorphism was not associated with susceptibility to endometriosis and adenomyosis in the population studied.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

MeSH descriptors

5' Untranslated Regions Endometriosis Genetic Predisposition to Disease Polymorphism, Single Nucleotide Promoter Regions, Genetic Vascular Endothelial Growth Factor A Adult Biophysical Phenomena Endometriosis Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Polymorphism, Genetic Vascular Endothelial Growth Factor A

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (11)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:11.755070+00:00
License: CC0 · commercial use OK