{"paper_id":"cc2cfb33-d6bc-4469-bd70-295364287143","body_text":"Abstract\nPurpose\nThe vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis.\nMethods\nBy searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated.\nResult\nAn association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT + TC vs. CC: OR 1.184, 95% CI 1.027–1.366, P = 0.020; TC vs. CC: OR 1.187, 95% CI 1.024–1.375, P = 0.023. Random-effcet model: TT + TC vs. CC: OR 1.203, 95% CI 1.003–1.443, P = 0.046; TC vs. CC: OR 1.188, 95% CI 1.021–1.382, P = 0.026). No association between VEGF genes −460CT, +405CG, −2578AC, −1154GA polymorphisms and endometriosis was observed.\nConclusion\nOur results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not −460CT, +405CG, −2578AC, −1154GA.\nSimilar content being viewed by others\nReferences\nGiudice LC, Kao LC (2004) Endometriosis. Lancet 364(9447):1789–1799. doi:10.1016/S0140-6736(04)17403-5\nSimpson ER (2000) Role of aromatase in sex steroid action. J Mol Endocrinol 25(2):149–156 pii:JME00938\nTaylor RN, Lebovic DI, Mueller MD (2002) Angiogenic factors in endometriosis. Ann N Y Acad Sci 955:89–100 discussion 118, 396–406\nMcLaren J, Prentice A, Charnock-Jones DS, Millican SA, Muller KH, Sharkey AM, Smith SK (1996) Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. 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Hum Reprod 17(6):1415–1423\nAcknowledgments\nWe thank the following individuals for helpful comments at various stages of the review process: YunFei Cao, Fan Xu.\nConflict of interest\nThe authors declare that they have no conflicts of interest relevant to the manuscript.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nLiang, S., Huang, Y. & Fan, Y. Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis. Arch Gynecol Obstet 286, 139–146 (2012). https://doi.org/10.1007/s00404-012-2270-1\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-012-2270-1","source_license":"CC0","license_restricted":false}