Tissue and endocrine responses to gestrinone and danazol in the treatment of endometriosis

Forbes KL, K. Forbes, K L Forbes, F J Thomas, F. Thomas, Thomas FJ
Reproduction, fertility, and development · 1993 · vol. 5(1) , pp. 103–109 · doi:10.1071/rd9930103 · PMID:8234886 · W2002158099
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Gestrinone and danazol similarly reduced active endometriotic lesions, with gestrinone causing increased free testosterone and both drugs yielding comparable androgenic side effects.

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Abstract

An open comparative study of gestrinone and danazol in the treatment of endometriosis demonstrated a similar decrease in the extent of active endometriotic deposits, assessed visually following therapy. Biochemical endocrinological changes during therapy with gestrinone showed that basal concentrations of gonadotrophin remained unchanged, oestradiol concentrations varied and the free fraction of testosterone increased. A similar range of side effects was reported in both treatment groups, consisting predominantly of 'androgenic' effects in 10 of 15 women treated with gestrinone and 5 of 12 treated with danazol. The results suggest that gestrinone is an effective alternative agent for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Gestrinone Amenorrhea Amenorrhea Danazol Danazol Endometriosis Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Gestrinone Gestrinone Humans Luteinizing Hormone Luteinizing Hormone Sex Hormone-Binding Globulin Sex Hormone-Binding Globulin

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

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