Tissue and endocrine responses to gestrinone and danazol in the treatment of endometriosis
Non-randomised trial
OA: closed
CC0
⤵ 3 in-corpus citations
AI-generated summary
Gestrinone and danazol similarly reduced active endometriotic lesions, with gestrinone causing increased free testosterone and both drugs yielding comparable androgenic side effects.
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Abstract
An open comparative study of gestrinone and danazol in the treatment of endometriosis demonstrated a similar decrease in the extent of active endometriotic deposits, assessed visually following therapy. Biochemical endocrinological changes during therapy with gestrinone showed that basal concentrations of gonadotrophin remained unchanged, oestradiol concentrations varied and the free fraction of testosterone increased. A similar range of side effects was reported in both treatment groups, consisting predominantly of 'androgenic' effects in 10 of 15 women treated with gestrinone and 5 of 12 treated with danazol. The results suggest that gestrinone is an effective alternative agent for the treatment of endometriosis.
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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (16)
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Cited by (3)
- Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment 2013
- Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats 1998
- Voice changes in women treated for endometriosis and related conditions: the need for comprehensive vocal assessment 1998
Source provenance
- europepmc
- last seen: 2026-10-14T06:08:39.101224+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:59:25.815134+00:00
- unpaywall
- last seen: 2026-10-14T06:23:58.021457+00:00
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