The effects of certain angioneogenesis inhibitors in experimental endometriosis in rats

A Barbe, A. Berbets, И. С. Давыденко, V. Yuzko, О. M. Yuzko
In: Cell and Organ Transplantology · 2019 · vol. 7(2) · doi:10.22494/cot.v7i2.101 · W2998520104
article OA: hybrid CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the effects of specific anti-angiogenesis inhibitors on experimental endometriosis in a rat model.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper studied whether the dopamine agonist cabergoline and the highly selective COX-2 inhibitor celecoxib reduce ectopic lesion formation in a rat model of external genital endometriosis induced by surgical implantation of autologous uterine fragments. In 83 outbred sexually mature nulliparous Wistar rats, the dopamine agonist administered alone produced a pronounced inhibitory effect on ectopic endometrioid formation, while celecoxib alone showed significantly lower efficacy than cabergoline. The authors found that combining cabergoline with celecoxib did not lead to potentiation or additive effects. This paper is centrally about endometriosis—specifically testing dopamine- and COX-2–targeted angiogenesis inhibition (via VEGF-related pathways) to suppress experimental ectopic endometrial lesion formation in rats.

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Abstract

Endometriosis is a chronic benign hormone-dependent condition when the endometrial tissue, identical with the endometrium by its morphological and functional properties, grows outside the borders of the uterine mucous membrane. It leads to clinical symptoms able to affect the physical condition, psychological status and social status of the patient According to research data endometriosis is diagnosed in 5-10 % of the female population. There are approximately 176 million women with endometriosis in the world, mainly of a reproductive age.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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