Expression of epidermal growth factor, fibroblast growth factor‐2, and platelet‐derived growth factor‐A in the eutopic endometrium of women with endometriosis
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Platelet-derived growth factor-A mRNA was significantly lower in the secretory phase endometrium of women with endometriosis compared to controls.
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Abstract
AIM: The objective of the present study was to compare the levels of expression of epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), and platelet-derived growth factor-A (PDGF-A) mRNA in the eutopic endometrium of women with and without endometriosis. METHODS: Thirty-five women with advanced stage endometriosis and 31 control women were recruited. Following isolation of total RNA from endometrial tissue and reverse transcription, cDNA samples were amplified to quantify the level of expression of EGF, FGF-2, PDGF-A. RESULTS: While the levels of mRNA of EGF and FGF-2 were not different between the two groups, the PDGF-A mRNA level was significantly lower in the endometriosis group than in the control group during the secretory phase (6.12 +/- 0.51 vs 12.50 +/- 0.99, mean +/- SEM, P < 0.05). CONCLUSION: The expression level of PDGF-A, but not EGF and FGF-2, might be decreased during the secretory phase in the eutopic endometrium of women with advanced stage endometriosis.
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Cited by (13)
- The association between genetically predicted systemic inflammatory regulators and endometriosis: A bidirectional Mendelian randomization study 2024
- Upregulation of fibroblast growth factor 2 contributes to endometriosis through SPRYs/DUSP6/ERK signaling pathway 2021
- Expression of nerve growth factor (NGF) in endometrium as a potential biomarker for endometriosis – Single tertiary care centre study 2020
- Cytokine and growth factor profile in endometriosis: a multiplex analysis of peritoneal fluid to assess diagnostic utility 2020
- Bioinformatics strategy for the screening of key genes to differentiate adenomyosis from endometriosis (Review) 2019
- The role of growth factors in the pathogenesis of endometriosis 2019
- Endometrial biomarkers for the non-invasive diagnosis of endometriosis 2016
- Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment 2013
- Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis 2009
- Expression and Role of Peptides, Proteins and Growth Factors in the Pathogenesis of Endometriosis 2009
- Expression of the Epidermal Growth Factor Receptor Family in Correlation to the Estrogen Receptor α Expression in Peritoneal and Ovarian Endometriosis 2009
- Expression of the epidermal growth factor receptor family in correlation to the estrogen receptor a expression in peritoneal and ovarian endometriosis 2009
- Expression of the Epidermal Growth Factor System in Eutopic Endometrium from Women with Endometriosis Differs from That in Endometrium from Healthy Women 2008
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