Regression of experimentally induced endometriosis with a new selective cyclooxygenase-2 enzyme inhibitor

İsmail Kılıço, Ismail Kilico, Kilico I, Arif Kokcu, Arif Kökçü, Kokcu A, Kefeli M, Mehmet Kefeli, Kandemir B, Bedri Kandemir, Bedrı Kandemır
Gynecologic and obstetric investigation · 2013 · vol. 77(1) , pp. 35–39 · doi:10.1159/000356686 · PMID:24296832 · W1971047634
Other OA: closed CC0 ⤵ 10 in-corpus citations
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Dexketoprofen trometamol, a selective COX-2 inhibitor, significantly reduced the size, weight, and tissue components of experimentally induced endometriotic cysts in rats.

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Abstract

BACKGROUND: Cyclooxygenase-2 (COX-2) levels increase in women with endometriosis. COX-2, via increasing prostaglandin E2, contributes to an increase in vascular endothelial growth factor. In this way, COX-2 may contribute to the progression and continuity of endometriosis. We investigated the effect of dexketoprofen trometamol, a new selective COX-2 enzyme inhibitor, on experimentally induced endometriotic cysts. METHODS: Experimental endometriotic cysts were created in 60 adult female Wistar albino rats. The rats were randomized to 2 equal groups, a control (group Con) and a dexketoprofen (group Dex) group. Six weeks later, cyst volumes were measured as in vivo (volume 1). Following volume 1 measurement, for 4 weeks group Con received 0.1 ml distilled water; group Dex received 0.375 mg dexketoprofen trometamol/0.1 ml distilled water, intramuscularly, twice a day. At the end of administration, the cyst volumes were remeasured (volume 2), and the cysts totally excised and weighed. Glandular (GT) and stromal tissues (ST) and natural killer (NK) cell contents in the cyst wall were scored. RESULTS: NK cell content and volume 1 were not different between the 2 groups. Volume 2, cyst weight, and GT and ST contents in group Dex were significantly lower than those in group Con. CONCLUSION: Dexketoprofen trometamol significantly reduced the development of experimentally induced endometriotic cysts both macroscopically and microscopically.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Inhibitors Endometriosis Ketoprofen Tromethamine Animals Animals Cyclooxygenase 2 Inhibitors Cyclooxygenase 2 Inhibitors Disease Models, Animal Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometriosis Female Female Ketoprofen Ketoprofen Ketoprofen Killer Cells, Natural

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

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