Local Immune Response in Infertile Patients with Minimal Endometriosis

Nomiyama M, M Nomiyama, Mari Nomiyama, T Hachisuga, Hachisuga T, Toru Hachisuga, H Sou, Hiroko Sou, Sou H, Nakamura K, Kayoko Nakamura, K. Nakamura, Matsumoto Y, Y Matsumoto, Yumi Matsumoto, T Iwasaka, Tsuyoshi Iwasaka, Iwasaka T, H Sugimori, Sugimori H
Gynecologic and obstetric investigation · 2010 · vol. 44(1) , pp. 32–37 · doi:10.1159/000291405 · PMID:9251951 · W2059926622
article OA: closed CC0 ⤵ 14 in-corpus citations
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Minimal endometriosis patients with lymphocytic infiltration in implants showed more T-cell infiltration without affecting systemic immunity or pregnancy rates compared to controls.

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Abstract

Objective: To evaluate the role of local immunity in women with minimal endometriosis. Methods: Uterine endometrium and endometrial implants were obtained simultaneously from 30 infertile women with minimal endometriosis and examined immunohistochemically using antibodies of T cell, B cell, macrophage, Langerhans cell, immunoglobulin (Ig)G and complement (C) 3d. Serum IgG, IgA, IgM, C3, C4, antinuclear antibody and anti-DNA antibody were also examined in 24 of the women. Data from uterine endometrium and serum were compared with 10 fertile women without endometriosis as a control. Results: Microscopic examination revealed that the endometrial implants were divided into two groups: group 1 (n = 13) showed lymphocytic infiltration in the endometrial implants and group 2 (n = 17) showed no or slight lymphocytic infiltration. The endometrial implants of group 1 showed significantly more dense T-cell infiltration than those of group 2. Other types of infiltrating cells and deposits of IgG and C3d revealed no significant differences between groups 1 and 2. The immunohistochemical examination of the uterine endometrium and the serum data revealed no significant differences among all three groups. Cumulative pregnancy rates showed no significant difference between groups 1 and 2. Conclusion: The difference of local immune response in endometrial implants did not affect systemic immunity.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Immunity Infertility, Female Adult B-Lymphocytes B-Lymphocytes Complement C3 Complement C3 Complement C4 Complement C4 Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Immunoenzyme Techniques Immunoglobulin A Immunoglobulin A

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