Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis

Kim JG, J. G. Kim, Jung Gu Kim, Suh CS, C S Suh, Chang Seok Suh, Kim SH, Seok Hyun Kim, S H Kim, Young Min Choi, Choi YM, Y. M. Choi, Shin Yong Moon, S Y Moon, Moon SY, Lee JY, J Y Lee, Jin Yong Lee
Fertility and sterility · 2000 · vol. 73(5) , pp. 996–1000 · doi:10.1016/s0015-0282(00)00493-3 · PMID:10785227 · W2157528128
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This study investigated insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis.

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Abstract

OBJECTIVE: To compare levels of insulin-like growth factor (IGF) components in the peritoneal fluid of patients with and without endometriosis. DESIGN: Patients with endometriosis were compared with control patients. SETTING: Seoul National University Hospital, Korea. PATIENT(S): Forty-three patients with endometriosis and 20 patients without endometriosis. INTERVENTION(S): Peritoneal fluid specimens were collected. MAIN OUTCOME MEASURE(S): Insulin-like growth factors, IGF binding protein (IGFBP) profiles and IGFBP-3 protease activity. RESULT(S): The IGF-I levels in peritoneal fluid were significantly higher in patients with endometriosis than in control patients, while the IGFBP-3 levels and the relative proportion of IGFBP-2 in peritoneal fluid were significantly lower in patients with endometriosis than in control patients. However, IGF-II levels, IGFBP-4 profiles, and IGFBP-3 protease activity did not differ significantly between the two groups. No correlation between these IGF components in peritoneal fluid and the stage of endometriosis was noted. CONCLUSION(S): The profiles of IGF components in peritoneal fluid of patients with pelvic endometriosis may play an important role in the growth of ectopic endometrium and endometriosis-induced infertility.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endopeptidases Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor I Insulin-Like Growth Factor II Adult Adult Ascitic Fluid Ascitic Fluid Body Mass Index Body Mass Index Endometriosis Endometriosis Endopeptidases Endopeptidases Humans Humans Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor Binding Proteins

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