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Exposure to harmful environments during pregnancy and maternal nutritional status are key factors that affect offspring development; however, the underlying mechanisms of maternal-fetal interaction remain to be elucidated. In recent years, …

OBJECTIVE: The research focuses on understanding how GSDMD and Caspase-1, key regulators of pyroptosis, influence postoperative recurrence in Endometrial Polyps (EPs) and examines whether a combined biomarker can effectively predict recurre…

Stem cells, with their self-renewal and multi-lineage differentiation potential, hold promise for tissue repair and intractable diseases treatment. Yet clinical translation of stem cell therapies has long been hindered by insufficient scala…

BACKGROUND: Reactive nodular fibrous pseudotumor is a rare benign fibroinflammatory lesion of the gastrointestinal tract and mesentery that can closely mimic malignant disease on clinical examination and imaging. Most reported cases are ass…

Introduction Uterine rupture (UR) during pregnancy refers to a disruption of the uterine wall involving the myometrium and serosa that occurs in association with pregnancy. The global incidence of UR is rising, and this condition can lead t…

RESEARCH QUESTION: While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive. This study assesses the effect of GH supplementation on embryo quality…

BACKGROUND: Uterine prolapse (UP), a subtype of pelvic organ prolapse (POP), frequently coexists with urinary tract infections (UTIs) and lower urinary tract symptoms (LUTS), including urinary frequency (UF), urinary incontinence (UI), and …

Nanomaterials are increasingly applied in biomedicine and have significant potential in reproductive medicine. However, because they can impact germ cells, use of nanomaterials could represent a "double-edged sword", whose benefits must be …

OBJECTIVES: Some previous studies examined the knowledge, attitudes, and practices (KAP) toward prenatal genetic testing of the fetus but not toward blood chromosomal testing in the preconception and premarital period. This study investigat…

Conventional treatments for advanced endometriosis often have limited efficacy due to chemotherapy resistance, recurrence, and metastasis. This study analyzed clinical specimens to investigate the role of NXF1 in endometrial cancer (ECa) pr…

Background: The stress hyperglycemia ratio (SHR) has emerged as a promising biomarker for assessing stress-induced hyperglycemia (SH) but has not been evaluated in patients with acute pancreatitis (AP). This study investigates the role of t…

Perianal endometriosis represents a rare form of endometriosis occurring outside the pelvic cavity. Owing to its infrequency in clinical practice, this condition is highly susceptible to misdiagnosis and inappropriate treatment. This case r…

BACKGROUND: The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be attributed to the absence of histone protection and complete repair mechanisms. Mitochondrial heteroplasmy refers to the coexistence of wild-type and mutant m…

Objectives: This study aims to analyze the clinical characteristics of elderly patients with acute pancreatitis (AP) and investigate the effects of age on the clinical outcomes of AP. Methods: Patients aged ≥ 18 years with AP admitted withi…

Abstract Background The human body harbors greater than 10 trillion symbiotic, microbial cells that contribute to our bodily functions. Emerging evidences suggest that dysbiosis, especially of the gut or urogenital system, may induce vari…

BACKGROUND: Embryo implantation in a receptive endometrium is crucial for successful pregnancy. Endometrial receptivity (ER) prediction tools based on endometrial transcriptome biomarkers by endometrial biopsy have been used to guide succes…

Dong Liu,1,* Huanhuan Wei,2,* Jinyu Huang,1 Hailin Shen,3 Ximing Wang,1 Chunhong Hu1 1Radiological Department, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Academy of Medical Sciences, the People…

BACKGROUND: Endometriosis developing in a cesarean section (CS) scar is an unusual event. Malignant transformation arising on the background of scar endometriosis in the abdominal wall is extremely rare. Herein we report a case of clear cel…

Xinyu Nie,1,2 Xinru Dong,1,2 Yuge Hu,1,2 Fangjun Xu,1 Cong Hu,2 Chang Shu1 1Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Reproductive Medicine Center, Prenatal Diagnosi…

Myeloid-derived suppressor cells (MDSCs) are a novel heterogenous group of immunosuppressive cells derived from myeloid progenitors. Their role is well known in tumors and autoimmune diseases. In recent years, the role and function of MDSCs…

STUDY QUESTION: Can whole exome sequencing (WES) followed by trio bioinformatics analysis identify novel pathogenic genetic causes of first trimester euploid miscarriage? SUMMARY ANSWER: We identified genetic variants in six candidate gene…

BACKGROUND: Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predomi…

ETHNOPHARMACOLOGICAL RELEVANCE: In the practice of traditional Chinese medicine, endometriosis is believed to be caused by blood stasis and is characterised by dysmenorrhea, which is difficult to control. Shixiao San (SXS) has a long histor…

Liquid biopsy has been rapidly developed in recent years due to its advantages of non-invasiveness and real-time sampling in cancer prognosis and diagnosis. Exosomes are nanosized extracellular vesicles secreted by all types of cells and ab…

AIM: The aim of this study was to assess the risk factors for coexisting deep endometriosis (DE) in patients with recurrent ovarian endometrioma (OE). METHODS: We retrospectively reviewed 151 recurrent OE patients who had been diagnosed of…