Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model

Ji X, Xiayun Ji, Gao J, Jian Gao, Xueting Cai, Cai X, Wuguang Lu, Lu W, Hu C, Chunping Hu, Zhigang Wang, Wang Z, Cheng X, Xiawei Cheng, Zhenhua Gu, Gu Z, Wan G, Guiping Wan, Shuangquan Zhang, Zhang S, Cao P, Peng Cao
Journal of ethnopharmacology · 2011 · vol. 134(3) , pp. 624–629 · doi:10.1016/j.jep.2011.01.003 · PMID:21220004 · W2057352931
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This study investigated the immunological regulation of Guizhi Fuling Capsule on a rat model of endometriosis, observing its effects on immune cell activity and inflammatory markers.

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Abstract

AIM OF THE STUDY: To investigate the immunological regulation of Guizhi Fuling Capsule (GZFLC) on rat endometriosis. MATERIALS AND METHODS: Twenty-seven rats, in which endometriotic implants were induced by transplanting autologous uterine tissue to the peritoneum, were randomly divided into three groups equally: (1) the GZFLC group of low dose (480 mg/kg/day); (2) the GZFLC group of high dose (1,920 mg/kg/day); and (3) the model group(saline solution). Another 10 rats were treated as sham operation group. After rats were treated for four weeks, we examined the alterations of implants volume, the percentage of CD4(+) T lympholeukocyte, the activity of NK cell and the expression of cytokines (MCP-1 and ICAM-1) on each group. RESULTS: Statistical analysis showed that posttreatment volumes were significantly reduced compared with pretreatment in GZFLC groups, whereas there was no significant change in the model group. The percentage of CD4(+) T lympholeukocyte and the activity of NK cell in GZFLC groups significantly increased to the level of the sham group compared with the model. RT-PCR and immunohistochemistry showed that the endometria of the sham operation and treatment groups were similar on expression level of MCP-1 and ICAM-1. CONCLUSIONS: GZFLC plays an important role in the regression of endometriotic implants by immunological regulation in the rat model.

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Condition tags

endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Animals Animals Base Sequence Base Sequence CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes Chemokine CCL2 Chemokine CCL2 Chemokine CCL2 Disease Models, Animal Disease Models, Animal DNA Primers DNA Primers Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

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