The effect of a luteinizing hormone-releasing hormone antagonist on experimental endometriosis in the rat
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Subcutaneous administration of a luteinizing hormone-releasing hormone antagonist inhibited experimental endometriosis in rats, with significant growth reduction observed at higher doses, though explant growth resumed after treatment cessation.
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Abstract
The effect of a Salk LRH analogue (Antagonist I) on growth of endometrial explants in the intact female rat was studied. Subcutaneous injection of the analogue was begun 3 weeks after transplantation of a section of endometrium to the peritoneal wall. The animals were laparotomized and the volume of the explant (length X width X height) in mm was measured with calipers on day 1 of treatment. The animals were injected daily for 3 weeks with 50, 250 or 500 micrograms of Antagonist I at which time the animals were again laparotomized and the volume of the explant measured. Eight weeks after cessation of treatment the animals were sacrificed and the volume of the explant measured. The degree of inhibition of explant growth was directly correlated with the amount of Antagonist I administered; a significant inhibition was obtained with doses of 250 or 500 micrograms. Eight weeks after cessation of treatment all explants demonstrated renewed growth, although explants in rats which had been treated with 250 or 500 micrograms had returned to only 51 and 61% of their initial volume, respectively. The results of this study demonstrate the LRH antagonists may be useful in the treatment of endometriosis although at doses considerably higher than those of the super agonists.
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Cited by (17)
- Huayu Sanjie Enema Liquid Relieves Pain in Endometriosis Model Rats by Inhibiting Inflammation, Peripheral Sensitization, and Pelvic Adhesion 2022
- WITHDRAWN: Endometriosis related sex steroid hormones, hypothalamic pituitary gonadal axis hormones and related animal modeling: A comprehensive review of published articles and endometriosis induction methods from 2010 to 2021 with scoring based approach 2021
- Caulis Sargentodoxae Prescription Plays a Therapeutic Role with Decreased Inflammatory Cytokines in Peritoneal Fluid in the Rat Endometriosis Model 2020
- Effect of Physical Exercise on Endometriosis Experimentally Induced in Rats 2018
- <i>Jing Tong Yu Shu</i>, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis 2018
- Influência da doxiciclina em endometriose experimentalmente induzida em ratas 2018
- Elagolix, a Novel, Orally Bioavailable GnRH Antagonist under Investigation for the Treatment of Endometriosis-Related Pain 2015
- Effects of natural progesterone on endometriosis in an experimental rat model: is it effective? 2014
- Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model 2011
- Medical treatment of endometriosis. 2009
- Investigational drugs for endometriosis 2006
- Leflunomide—an Immunomodulator—Induces Regression of Endometrial Explants in a Rat Model of Endometriosis 2006
- Future Perspectives in the Medical Treatment of Endometriosis 2005
- New medical treatments for endometriosis 2004
- Medical Therapy for Endometriosis 2003
- Using Rats as a Research Model for the Study of Endometriosis 2002
- Spontaneous and steroid-induced recurrence of endometriosis after suppression by a gonadotropin-releasing hormone antagonist in the rat 1991
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