Acta endocrinologica

GnRH agonists can induce a reversible pharmacological menopause and can be used to treat endometriosis, a fairly common gynaecological problem which responds well to oestrogen deprivation. Premature menopause is associated with adverse lipi…

We have recently identified a uterine progesterone-dependent 25 kD protein (protein #27) secreted by endometrial epithelial cells but not stroma. Protein #27 was originally isolated from human luteal phase uterine fluids and partially purif…

To investigate the effects of medical treatment of endometriosis on concentrations of insulin and glucagon in comparison with those of androgens, 12 non-obese women with minimal endometriosis were randomly allocated to receive treatment wit…

Estrogen biosynthesis (aromatase activity) was investigated in human adenomyosis tissue and compared with that of the normal myometrium, endometrium, and endometrial cancer tissues. Homogenates were incubated with [1,2,6,7-3H]androstenedion…

The effect of danazol on progesterone formation was studied in cultured human granulosa cells obtained from 20 follicles in the mid- to late follicular phase of normally menstruating women. The cells were cultured for 2 to 6 days in the pre…

The effect of a Salk LRH analogue (Antagonist I) on growth of endometrial explants in the intact female rat was studied. Subcutaneous injection of the analogue was begun 3 weeks after transplantation of a section of endometrium to the perit…

The effect of different schedules of bromocriptine-mesilate (CB-154; 0.2 mg/day) treatment on the development of precancerous mammary hyperplastic alveolar nodules (HAN) and uterine adenomyosis was investigated in a virgin SHN strain of mic…

A group of 55 women with endometriosis was studied before and during danazol therapy. An unexpectedly high proportion (36%) had a raised serum prolactin level before treatment which was reduced after 50 days of danazol (before treatment 783…

The effect of the LRH agonist, Wy-40,972, levonorgestrel or danazol on growth of endometrial explants in the intact female rat was studied. Sc injection of a single compound was begun 3 weeks after transplantation of a section of endometriu…

Seven patients suffering from severe endometriosis were treated with danazol 200 mg X 3 daily for 6 months. Clinical symptoms were alleviated and menses disappeared in response to the treatment. After cessation of the treatment the menstrua…

The administration of danazol, 200 mg three times daily, from the 3rd to the 23rd day of the cycle to normally menstruating women exhibited the following actions on the human endometrium: significantly reduced cytosol oestrogen and progesti…

Abstract. The effect of oral metoclopramide 10 mg three times daily during the follicular and periovulatory period on Prl, LH, FSH, oestradiol and progesterone was determined in 6 regularly menstruating women. During a control cycle and a t…

The relationship between the biological and immunological activities of human luteinizing hormone (hLH) in plasma collected from female subjects was examined. The biological activity was measured by an in vitro bioassay and the immunologica…

Isolation of the corticosteroid-binding globulin CBG was achieved by 5 chromatographical steps on cortisol Sepharose, QAE-Sephadex A-50, Con A-Sepharose and hydroxylapatite. The purity of the isolated CBG was demonstrated in polyacrylamide …

The concentrations of endometrial oestrogen and progesterone receptors, both in cytosol and in nuclei, have been studied at 8--10 weeks and at 38--40 weeks of gestation. At these two periods the concentration of oestrogen receptors is compa…

ABSTRACT Hypophysectomy was performed at the same time as ovariectomy in 19 rats aged 6 weeks; in addition a fragment of the animal's own ovary was implanted into the greater omentum. The graft took but there was complete cessation of the g…

ABSTRACT Ovariectomized and hemi-ovariectomized 3 week old non-littermate rats bearing ovarian implants on the greater omentum were parabiosed by coelio-anastomosis. Controls consisted of 67 spayed and 58 hemi-spayed single animals with sim…

ABSTRACT A group of 104 post-menopausal women, who were at least 50 years old and with a time lapse of at least 2 years since the last menstruation, were investigated for their urinary oestrogen content. All the women had an atrophic endome…

ABSTRACT Virgin mice received 2 blastocysts under the kidney capsule. Following an oestrous cycle which occurred 1–4 days after the operation, nearly all the animals became pseudopregnant. It was found that pseudopregnancy induced by ectopi…

ABSTRACT The plasma level of progesterone in 30 clinically normal women on the estimated 5th to 7th day after ovulation, determined by combined paperand gas-chromatography, was 1.39 μg/100 ml ± 0.14 S. E. The response of eight women to a si…

ABSTRACT The influence of total abdominal hysterectomy on the corpus luteum activity in women has been investigated. Urinary pregnane-3α,20α-diol determinations and vaginal smears indicated that hysterectomy performed on day 17–18 of the cy…

ABSTRACT In rats bearing a transplanted immature ovary under the kidney capsule, the in situ ovaries were removed at oestrus. In spite of this operation the sequence of vaginal oestrous cycles was uninterrupted. Removal of the in situ ovari…

ABSTRACT Continuous treatment with 17α-methyl-19-nortestosterone (MNT) (5 – 2.5 – 1 mg daily) or 17α-ethinyl-17β-hydroxy-estr-4-en (Lynestrenol) (LNL) (5 – 2.5 mg daily), progestogenic norderivatives, can produce a state of prolonged amenor…

ABSTRACT The effects of a single administration of 1 mg ergocornine methane-sulphonate to female rats with functional corpora lutea have been studied. It was shown that: 1) Injection of ergocornine into hypophysectomized rats bearing an aut…