Influence of danazol and goserelin on insulin and glucagon in non-obese women with endometriosis

I. M. Golland, Golland IM, Catherine A. Vaughan-williams, C A Vaughan-Williams, Vaughan-Williams CA, S M Shalet, Shalet SM, S Shalet, I Laing, Laing I, Ian Laing, Max Elstein, Elstein M, M Elstein
Acta endocrinologica · 1990 · vol. 123(4) , pp. 405–410 · doi:10.1530/acta.0.1230405 · PMID:2146853 · W1968934545
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Danazol treatment significantly increased insulin and glucagon levels in women with endometriosis, while goserelin did not, and the increased free testosterone index from danazol was not correlated with these hormonal changes.

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Abstract

To investigate the effects of medical treatment of endometriosis on concentrations of insulin and glucagon in comparison with those of androgens, 12 non-obese women with minimal endometriosis were randomly allocated to receive treatment with either danazol or the gonadotropin-releasing hormone analogue, goserelin. In subjects treated with danazol, mean (SD) summed serum insulin (1.08 (0.22) nmol/l pretreatment; 3.00 (1.50) nmol/l after treatment, p less than 0.05) and summed plasma glucagon (94 (21) pmol/l pretreatment; 238 (113) pmol/l after treatment, p less than 0.05) responses to oral glucose administration increased significantly, but remained unchanged in subjects treated with goserelin. In the danazol-treated group, the mean free testosterone index increased from 3.3 (1.6) to 13.3 (4.2) (p less than 0.01), but there was no correlation between either glucagon or insulin and free testosterone index. In the goserelin-treated subjects, however, there was no change in mean free testosterone indices (pretreatment 3.6 (1.0), post-treatment 3.9 (1.8). Thus, the increase in free testosterone index induced by danazol treatment is not responsible for the concomitant development of hyperinsulinaemia and hyperglucagonaemia.

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Condition tags

endometriosis

MeSH descriptors

Buserelin Danazol Endometriosis Glucagon Insulin Adult Androgens Androgens Blood Glucose Blood Glucose Buserelin Buserelin Buserelin C-Peptide C-Peptide Danazol Danazol Endometriosis Endometriosis Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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