Effects of natural progesterone on endometriosis in an experimental rat model: is it effective?

R Narin, Raziye Narin, H Nazik, Hakan Nazik, H Aytan, Hakan Aytan, Mehmet Ali Narin, M A Narin, M Api, Murat Apı, K Dağlioğlu, Kenan Dağlıoğlu, S. Büyüknacar Büyüknacar, S Büyüknacar, Deniz Aka Satar, D Aka Satar, F Adamhasan, Fulya Adamhasan
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(4) , pp. 455–459 · doi:10.12891/ceog17632014 · PMID:25134298 · W2417782503
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Natural progesterone treatment reduced endometriotic lesion size and improved histological scores in rats with surgically induced endometriosis.

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This study evaluated whether natural progesterone affects endometriosis using a rat model in which endometriosis was surgically induced by transplanting autologous endometrial tissue onto the inner abdominal wall. Twenty rats were assigned to control (no medication) or a progesterone-treated group that received 2.5 mg/kg weekly natural progesterone for four weeks, after which endometriotic lesion size was measured and lesions were assessed morphologically and histologically with epithelial preservation scoring. Natural progesterone was associated with reduced lesion size (p < 0.01) and lower histological scores versus controls (p = 0.014), though the paper notes that deaths occurred due to surgical complications (2 in the study group, 1 in control). This paper is centrally about endometriosis — testing natural progesterone’s effectiveness in an experimental rat endometriosis model.

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Abstract

UNLABELLED: To assess the effects of the natural progesterone on the endometriosis in a rat model. MATERIALS AND METHODS: Endometriosis was surgically induced in 20 rats by transplanting an autologous fragment of endometrial tissue onto the inner surface of the abdominal wall. Rats in control group had no medication but 2.5 mg/kg/weekly natural progesterone was administered to rats in study group for four weeks. After that, all rats were sacrificed and dimensions of endometriosis were measured and they were evaluated morphologically and histologically. Scoring systems were used to evaluate preservation of epithelia. RESULTS: Two rats in the study group and one rat in the control group died of complications related to surgery. At the end of the treatment, there was a reduction in the size of the endometriotic lesions in the study group (p < 0.01). According to histological evaluation, the study group had lower score than control goup which was statistically significant (p = 0.014). CONCLUSIONS: Natural progesterone is effective against endometriosis in rat model.
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Effects of natural progesterone on endometriosis in an experimental rat model: is it effective? R. Narin 1,*, H. Nazik 1, H. Aytan 2, M.A. Narin 1, M. Api 1, K. Dağlıoğlu Dağlıoğlu 3, S. Büyüknacar Büyüknacar 4, D. Aka Satar 5, F. Adamhasan 6 1 Department of Obstetrics and Gynecology, Numune Education and Research Hospital, Adana 2 Department of Obstetrics and Gynecology, Mersin University, Faculty of Medicine, Mersin 3 Faculty of Veterinary, Cukurova University, Adana 4 Faculty of Medicine, Department of Pharmacology, Cukurova University, Adana 5 Department of Hystology and Embryology, Numune Education and Research Hospital, Adana 6 Department of Pathology, Numune Education and Research Hospital, Adana (Turkey) Published: 10 Aug 2014 The Author(s). Published by IMR Press. This is an open access article under the CC BY 4.0 license. Abstract Purpose: To assess the effects of the natural progesterone on the endometriosis in a rat model. Materials and Methods: Endometriosis was surgically induced in 20 rats by transplanting an autologous fragment of endometrial tissue onto the inner surface of the abdominal wall. Rats in control group had no medication but 2.5mg/kg/weekly natural progesterone was administered to rats in study group for four weeks. After that, all rats were sacrificed and dimensions of endometriosis were measured and they were evaluated morphologically and histologically. Scoring systems were used to evaluate preservation of epithelia. Results: Two rats in the study group and one rat in the control group died of complications related to surgery. At the end of the treatment, there was a reduction in the size of the endometriotic lesions in the study group (p < 0.01). According to histological evaluation, the study group had lower score than control goup which was statistically significant (p = 0.014). Conclusions: Natural progesterone is effective against endometriosis in rat model.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Progesterone Progestins Animals Disease Models, Animal Endometriosis Endometriosis Epithelium Epithelium Epithelium Female Progesterone Progestins Rats Rats, Wistar

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