Jing Tong Yu Shu, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis

Tianchan Zhang, Huifang Cong, Shan Zhao, Qiao Zhang, Xumeng Gu
In: Tropical Journal of Pharmaceutical Research · 2018 · vol. 16(12) , pp. 2953 · doi:10.4314/tjpr.v16i12.20 · W2783022590
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Jing Tong Yu Shu (JTYS) treatment reduced endometriotic explant volume in rats by suppressing IL-1β and IL-6 gene expression in macrophages and lowering their levels in peritoneal fluid and serum.

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This study evaluated the therapeutic potential of Jing Tong Yu Shu, a traditional Chinese medicine, using a surgical rat model of endometriosis. Researchers induced endometriosis in forty female rats and administered varying doses of the herbal treatment over four weeks to assess its impact on lesion volume and inflammatory markers. The results demonstrated that the drug caused dose-dependent regression of endometriotic implants and significantly reduced the production of IL-1β and IL-6 by peritoneal macrophages. These findings indicate that Jing Tong Yu Shu effectively alleviates endometriosis symptoms by suppressing key pro-inflammatory cytokines in this animal model. This paper is centrally about endometriosis — specifically investigating the anti-inflammatory effects of a traditional Chinese medicine on endometriotic lesions.

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Abstract

Purpose: To evaluate the effect of a traditional Chinese medicine, Jing Tong Yu Shu (JTYS) on endometriosis in a rat surgical model. Methods: Endometriosis was induced in 40 female rats. The rats were randomly divided into 4 groups: three JTYS groups given different doses of the drug, and a saline group. After four weeks of treatment with JTYS, the volume of the endometriotic explants was measured, and the levels of IL-1β and IL-6 in peritoneal fluid and serum were determined by enzyme-linked immunosorbent assay (ELISA). The production of cytokine IL-1β and IL-6 by peritoneal macrophages was also measured for each group. Results: JTYS treatment brought about regression of implants and inhibition of IL-1β and IL-6 production in a dose-dependent manner, with high-dose JTYS eliciting 66.76 % reduction in mean endometriotic explant volume. Plasma and peritoneal fluid levels of IL-1β and IL-6 were significantly lower in the high-dose JTYS group than in the saline group (p < 0.05). However, JTYS treatment significantly inhibited IL-1β and IL-6 production in peritoneal macrophages (p < 0.05). Conclusion: These results suggest that JTYS treatment leads to regression of endometriotic lesions in rat. Thus, JTYS has the potential to be developed into a new drug for the treatment of endometriosis. Keywords: Endometriosis, Interleukins, Traditional Chinese medicine, Jing Tong Yu Shu Macrophages
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Abstract

Purpose: To evaluate the effect of a traditional Chinese medicine, Jing Tong Yu Shu (JTYS) on endometriosis in a rat surgical model.

Methods

Endometriosis was induced in 40 female rats. The rats were randomly divided into 4 groups: three JTYS groups given different doses of the drug, and a saline group. After four weeks of treatment with JTYS, the volume of the endometriotic explants was measured, and the levels of IL-1β and IL-6 in peritoneal fluid and serum were determined by enzyme-linked immunosorbent assay (ELISA). The production of cytokine IL-1β and IL-6 by peritoneal macrophages was also measured for each group.

Results

JTYS treatment brought about regression of implants and inhibition of IL-1β and IL-6 production in a dose-dependent manner, with high-dose JTYS eliciting 66.76 % reduction in mean endometriotic explant volume. Plasma and peritoneal fluid levels of IL-1β and IL-6 were significantly lower in the high-dose JTYS group than in the saline group (p < 0.05). However, JTYS treatment significantly inhibited IL-1β and IL-6 production in peritoneal macrophages (p < 0.05).

Conclusion

These results suggest that JTYS treatment leads to regression of endometriotic lesions in rat. Thus, JTYS has the potential to be developed into a new drug for the treatment of endometriosis.

Keywords

Endometriosis, Interleukins, Traditional Chinese medicine, Jing Tong Yu Shu Macrophages

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