Jing Tong Yu Shu, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis

Tianchan Zhang, Huifang Cong, Shan Zhao, Qiao Zhang, Xumeng Gu
In: Tropical Journal of Pharmaceutical Research · 2018 · vol. 16(12) , pp. 2953 · doi:10.4314/tjpr.v16i12.20 · W2783022590
article OA: gold CC0 ⤵ 2 in-corpus citations
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Jing Tong Yu Shu (JTYS) treatment reduced endometriotic explant volume in rats by suppressing IL-1β and IL-6 gene expression in macrophages and lowering their levels in peritoneal fluid and serum.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Purpose: To evaluate the effect of a traditional Chinese medicine, Jing Tong Yu Shu (JTYS) on endometriosis in a rat surgical model. Methods: Endometriosis was induced in 40 female rats. The rats were randomly divided into 4 groups: three JTYS groups given different doses of the drug, and a saline group. After four weeks of treatment with JTYS, the volume of the endometriotic explants was measured, and the levels of IL-1β and IL-6 in peritoneal fluid and serum were determined by enzyme-linked immunosorbent assay (ELISA). The production of cytokine IL-1β and IL-6 by peritoneal macrophages was also measured for each group. Results: JTYS treatment brought about regression of implants and inhibition of IL-1β and IL-6 production in a dose-dependent manner, with high-dose JTYS eliciting 66.76 % reduction in mean endometriotic explant volume. Plasma and peritoneal fluid levels of IL-1β and IL-6 were significantly lower in the high-dose JTYS group than in the saline group (p < 0.05). However, JTYS treatment significantly inhibited IL-1β and IL-6 production in peritoneal macrophages (p < 0.05). Conclusion: These results suggest that JTYS treatment leads to regression of endometriotic lesions in rat. Thus, JTYS has the potential to be developed into a new drug for the treatment of endometriosis. Keywords: Endometriosis, Interleukins, Traditional Chinese medicine, Jing Tong Yu Shu Macrophages

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK