Identification of Serum Biomarkers for Diagnosis of Endometriosis Using Multiplex Immunoassays

Heeyon Kim, Young Sik Choi, Jeong Sook Kim, Sinae Kim, Bo Hee Won, Young Bin Won, Inha Lee, Jae Hoon Lee, Bo Hyon Yun, Seok Kyo Seo, Joo Hyun Park, SiHyun Cho, Jung‐Ho Shin, Jung-Ho Shin, Jong‐Baeck Lim, Jong-Baeck Lim, Byung Seok Lee
Reproductive sciences (Thousand Oaks, Calif.) · 2020 · vol. 27(5) , pp. 1139–1147 · doi:10.1007/s43032-019-00124-2 · PMID:32046464 · W3006457697
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

A combination of APRIL/TNFSF13, BRAK/CXCL14, and CA-125 improved endometriosis detection sensitivity and specificity compared to CA-125 alone.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study aimed to identify serum biomarkers for diagnosing endometriosis by analyzing peripheral blood from 141 women aged 15–52 years with regular menstruation using a multiplex cytokine panel (21 detectable analytes) on the MILLIPLEX MAP platform. CXCL14/BRAK was significantly decreased and APRIL/TNFSF13 was significantly increased in the endometriosis group, but each marker alone or in combination did not achieve adequate diagnostic sensitivity or specificity. In logistic regression, adding CA-125 to the APRIL/TNFSF13 and BRAK/CXCL14 combination significantly improved sensitivity (71.2%) without reducing specificity (80.8%) compared with CA-125 alone. The paper does not report any explicit external validation or detailed limitations beyond noting the need for additional cytokine panels. This paper is centrally about endometriosis — it identifies candidate multiplex serum cytokine biomarkers (APRIL/TNFSF13 and BRAK/CXCL14, combined with CA-125) for noninvasive endometriosis diagnosis.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Adult Biomarkers Biomarkers CA-125 Antigen CA-125 Antigen Cytokines Endometriosis Endometriosis Female Humans Immunoassay

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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