Prediction Models of Endometriosis Stage Generated From Potential Hematological Biomarkers

Ayşe Rabia Şenkaya, Onur İnce, Alper İleri, Hakkı Aytaç, Suna Yıldırım Karaca
In: Aegean Journal of Obstetrics and Gynecology · 2023 · vol. 4(3) , pp. 52–56 · doi:10.46328/aejog.v4i3.123 · W4319603161
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study evaluated hematological biomarkers and found that serum CA125 levels, alone and combined with other markers, significantly correlated with endometriosis stage, with log(CA125) effectively predicting the stage.

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This retrospective surgical study evaluated whether hematological biomarkers could predict endometriosis stage, using patients diagnosed by pathology between January 2015 and December 2020 and grouped into stage 1–3 versus stage 4. The authors found no significant relationship between endometriosis score and complete blood count parameters, including ratios involving neutrophils/lymphocytes and platelet-related indices; however, endometriosis score correlated significantly with serum CA125 and with combined markers including CA125. A univariate linear model using log-transformed CA125 predicted endometriosis score, with the endometriosis score increasing by 8.57 units per unit increase in log(CA125) (β=8.57, R²=0.115, p0.263). The paper concludes CA125 alone was substantially efficient for preoperative prediction of endometriosis stage, while acknowledging limited explanatory strength via low R², and it does not explicitly discuss endometriosis-related clinical context beyond biomarker performance. This paper is centrally about endometriosis — it models preoperative endometriosis stage using CA125 and hematological biomarker candidates.

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Abstract

Objective: The aim of the study assess efficacy of hematological biomarkers for predicting the stage of endometriosis. Materials and methods: Patients underwent surgery and diagnosed with endometriosis confirmed by pathology report between January 2015-December 2020 were included. Individuals were divided into two groups as stage 1-2-3 and stage 4 patients. Results: 91 patients with stage 1-2-3 and 105 with stage 4 endometriosis were identified. There was no significant relationship between endometriosis score and complete blood count parameters. However, endometriosis score revealed a significant correlation with serum CA125 level and the combined markers including CA125. The logarithm of the CA 125 was used to predict the endometriosis score. In order to quantify the relationship, a univariate linear model was performed to predict the endometriosis score with log (CA 125). It demonstrated for every increase in the level of log (CA 125), endometriosis score increased by 8.57 (β=8.57. R2=0.115. p<0.001). The p values of alternative parameters analyzed to predict the stage of endometriosis. p-values were 0.263 for neutrophile/lymphocyte; 0.457 for platelet/lymphocyte; 0.790 for red cell distribution width/lymphocyte and 0.842 for mean platelet volume/lymphocyte ratios. Conclusion: CA 125 alone was found substaintally efficient in predicting endometriosis stage preoperatively.
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Objective

The aim of the study assess efficacy of hematological biomarkers for predicting the stage of endometriosis.

Materials and methods

Patients underwent surgery and diagnosed with endometriosis confirmed by pathology report between January 2015-December 2020 were included. Individuals were divided into two groups as stage 1-2-3 and stage 4 patients.

Results

91 patients with stage 1-2-3 and 105 with stage 4 endometriosis were identified. There was no significant relationship between endometriosis score and complete blood count parameters. However, endometriosis score revealed a significant correlation with serum CA125 level and the combined markers including CA125. The logarithm of the CA 125 was used to predict the endometriosis score. In order to quantify the relationship, a univariate linear model was performed to predict the endometriosis score with log (CA 125). It demonstrated for every increase in the level of log (CA 125), endometriosis score increased by 8.57 (β=8.57. R2=0.115. p<0.001). The p values of alternative parameters analyzed to predict the stage of endometriosis. p-values were 0.263 for neutrophile/lymphocyte; 0.457 for platelet/lymphocyte; 0.790 for red cell distribution width/lymphocyte and 0.842 for mean platelet volume/lymphocyte ratios.

Conclusion

CA 125 alone was found substaintally efficient in predicting endometriosis stage preoperatively. Downloads Published Issue Section License Copyright (c) 2023 Ayşe Rabia Şenkaya, Onur İnce , Alper İleri, Hakkı Aytaç, Suna Yıldırım Karaca This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. AEJOG is an open-access journal which means that through the internet; freely accessible, readable, downloaded, copied, distributed, printed, scanned, linked to full texts, indexed, transferred to the software as data and used for any legal purpose, without financial, legal and technical obstacles. The only authority on reproduction and distribution and the sole copyright role in this field; has been given to authors therefore they can have control over the integrity of their work, so that they are properly recognized and cited. This is in accordance with the BOAI definition of open access. The content in Aegean Journal of Obstetrics and Gynecology (AEJOG) is protected by copyright. All copyrights of the submitted articles are transferred to the Aegean Journal of Obstetrics and Gynecology within the national and international regulations at the beginning of the evaluation process. Upon submission of their article, authors are requested to complete an assignment of copyright release form. Authors should acknowledge that they will not submit their manuscript to another journal, publish in any other language, or allow a third party to use the article without the written consent of the Aegean Journal of Obstetrics and Gynecology. When an article is published on AEJOG, it is read and reused for free as soon as it is published under a Creative Commons Attribution-NonCommercial 4.0 (CC BY NC 4.0) license. In case the article is rejected, all copyrights are given back to the authors. The content of the article and all legal proceedings against the journal, if any, are the responsibility of the author. In addition, all financial and legal liability for the copyright of the presented tables, figures and other visual materials protected by law belongs to the authors. It is the responsibility of the corresponding author to report authors scientific contributions and responsibilities regarding the article. In case of any conflict of interest, it is the responsibility of the authors to indicate the conflict of interest in the Disclosure part of the article. Author names will be published as they are listed on the submitted Title page.

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Condition tags

endometriosis

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