Immunohistochemical localization of prostaglandin H synthase in the female reproductive tract and endometriosis

B J Van Voorhis, Bradley J. Van Voorhis, Phyllis C. Huettner, Huettner PC, P C Huettner, Martin R. Clark, M R Clark, Clark MR, J A Hill, Joseph A. Hill, Hill JA
American journal of obstetrics and gynecology · 1990 · vol. 163(1) , pp. 57–62 · doi:10.1016/s0002-9378(11)90667-x · PMID:1695815 · W1963712221
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This study investigated the presence and location of prostaglandin H synthase within the female reproductive tract and endometriosis tissue using immunohistochemistry.

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Abstract

Prostaglandin H synthase, also known as cyclooxygenase, is an essential enzyme in prostaglandin synthesis. Using a monoclonal antibody and immunohistochemical techniques, we studied the localization of this enzyme in the female reproductive tract and in endometriosis. In the uterus, prostaglandin H synthase was primarily localized to endometrial epithelium with surface epithelium containing more immunoreactive prostaglandin H synthase than glandular epithelium. Fallopian tube secretory epithelial cells also contained prostaglandin H synthase while ciliated epithelial cells did not. Cervical epithelium and myometrial cells did not contain prostaglandin H synthase. A higher percentage of glands in endometriosis and adenomyosis, as compared with eutopic endometrium, contained prostaglandin H synthase suggesting that these tissues are also capable of prostaglandin synthesis. These findings may have important physiologic significance in the mechanisms of embryo implantation, in menstruation, and in the pathophysiologic features of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genitalia, Female Prostaglandin-Endoperoxide Synthases Adult Cervix Uteri Cervix Uteri Endometriosis Endometriosis Endometrium Endometrium Endometrium Fallopian Tubes Fallopian Tubes Female Genitalia, Female Humans Immunohistochemistry Immunohistochemistry Middle Aged Prostaglandin-Endoperoxide Synthases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (11)

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