New understanding of TFEB and autophagy in the development of endometriosis：review

Qiu-yu Chen, Yu Zhao, sennan zhu, Yao Chen, Chenxi Dai, Zongwen Liang, qiong zhang
In: Authorea, Inc. · 2020 · doi:10.22541/au.160372865.59488613/v1 · W3105558671
preprint OA: gold CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review discusses the abnormal expression of TFEB, a key autophagy regulator, and its upstream/downstream molecules in endometriosis, suggesting TFEB as a potential therapeutic target.

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Abstract

Endometriosis is a benign gynecologic disease, but it is similar in behavior to malignant tumors, so it is called “benign gynecologic cancer”. At present, its pathogenesis is not fully understand. Autophagy has been the focus of recent research on various diseases, which has also been shown to have regulatory abnormalities in endometriosis. TFEB is a key regulator of autophagy. The upstream signal molecules and downstream effector proteins of TFEB have abnormal expression in endometriosis. So TFEB may be an effective target for controlling the development of endometriosis. This review aims to discuss the relationship between TFEB and endometriosis.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (79)

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License: CC0 · commercial use OK