A multifunctional nanoparticle for efferocytosis and pro-resolving-mediated endometriosis therapy

Qinkun Sun, Yihong Lei, Yi‐Hong Lei, Huaying Zhang, Xinyu Ding, Mengjie Yang, Teng Zhang, Jiahao Chen, Zhixiong Huang, Lemeng Wang, Jianfa Lan, Qiansheng Huang, Qionghua Chen
Colloids and surfaces. B, Biointerfaces · 2022 · vol. 220 , pp. 112893 · doi:10.1016/j.colsurfb.2022.112893 · PMID:36270139 · W4298132286
article OA: closed CC0 ⤵ 10 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Researchers developed a multifunctional nanoparticle to enhance efferocytosis and deliver pro-resolving mediators for treating endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is an inflammation-dependent disorder characterized by the abnormal growth of endometrium-like lesions. In recent years, there is a great deal of interest in the development of anti-inflammatory therapy. Herein, an acid-sensitive calcium carbonate nanoparticle (CaNP) incorporated BML-111 (BML@CaNP) was prepared. BML@CaNP acted as a Ca2+ nanomodulator for efferocytosis (macrophages engulf apoptotic cells). Specifically, BML@CaNP induced the apoptosis of endometriotic stromal cells and enhanced the efferocytosis of macrophages. In addition, the particle can also deliver BML to the ectopic lesion for resolving the inflammatory response. In vivo BML@CaNP effectively suppressed lesion growth in endometriosis mice model, which could be attributed to the enhancing efferocytosis of cells and the lower levels of inflammatory factors in peritoneal fluid. In addition, these nanoparticles did not show side effects. In all, we provide a new anti-inflammatory strategy by both enhancing efferocytosis and resolving inflammation for the treatment of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Multifunctional Nanoparticles Multifunctional Nanoparticles Multifunctional Nanoparticles Multifunctional Nanoparticles Multifunctional Nanoparticles Multifunctional Nanoparticles

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (41)

Cited by (10)

Source provenance

europepmc
last seen: 2026-06-19T06:14:56.452680+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-06-19T06:14:29.062243+00:00
License: CC0 · commercial use OK