Mitochondrial displacement loop alterations are associated with endometriosis

Suresh Govatati, Mamata Deenadayal, Deenadayal M, S. Shivaji, Sisinthy Shivaji, Manjula Bhanoori, Bhanoori M
Fertility and sterility · 2013 · vol. 99(7) , pp. 1980–1986.e9 · doi:10.1016/j.fertnstert.2013.02.021 · PMID:23490167 · W2097051761
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This study investigated alterations in the mitochondrial displacement loop (D-loop) and found associations with endometriosis.

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Abstract

OBJECTIVE: To evaluate the association of mitochondrial displacement (D-) loop alterations with endometriosis in south Indian women. DESIGN: Case-control study. SETTING: Biochemistry and molecular biology laboratories. PATIENT(S): Women with (n = 152) and without (n = 150) endometriosis of south Indian origin. INTERVENTION(S): All women had a transvaginal ultrasound scan at screening followed by a laparoscopy to confirm the diagnosis (revised American Fertility Society stage III = 54; stage IV = 98). MAIN OUTCOME MEASURE(S): Genotyping of entire D-loop (1,124 bp) was carried out on genomic DNA of blood from cases and controls by polymerase chain reaction sequencing analysis. RESULT(S): Twelve novel mutations and 187 reported polymorphisms were identified in the D-loop region of cases and/or controls. The A189G, 310 C insertion, T16189C polymorphisms, and 189G/310TC/16189C haplotype have significantly higher frequency in cases compared with controls. CONCLUSION(S): Mitochondrial D-loop alterations may constitute an inheritable risk factor for endometriosis. The analysis of D-loop alterations may help to identify patients at high risk for disease outcome.

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Condition tags

endometriosis

MeSH descriptors

DNA, Mitochondrial Endometriosis Mutation Mutation Polymorphism, Genetic Polymorphism, Genetic Adult Adult Case-Control Studies Case-Control Studies Chi-Square Distribution Chi-Square Distribution DNA, Mitochondrial DNA, Mitochondrial DNA Mutational Analysis DNA Mutational Analysis DNA Mutational Analysis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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Cited by (15)

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