Absence of activating somatic mutations of PI3KCA and AKT1 genes in South Indian women with endometriosis

Priyanka Rai, Rai P, Deenadayal M, Mamata Deenadayal, Sisinthy Shivaji, S. Shivaji
European journal of obstetrics, gynecology, and reproductive biology · 2010 · vol. 152(1) , pp. 78–82 · doi:10.1016/j.ejogrb.2010.04.022 · PMID:20493625 · W2111747648
article OA: closed CC0 ⤵ 3 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated the presence of activating somatic mutations in PI3KCA and AKT1 genes in South Indian women diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo investigate whether the PI3KCA and AKT1 gene influences the risk of developing endometriosis in South Indian women.Study designMutations in exon 9 and 20 of PI3KCA gene and E17K mutation in exon 4 of AKT1 gene were tested for association in a case-control study between eutopic and ectopic endometrium tissue from 30 endometriosis cases and eutopic endometrium tissue from 30 controls. The genotype frequencies of these mutations were compared using polymerase chain reaction and direct sequencing analysis of tissue DNA.ResultsThe analysis did not reveal any activating somatic mutations in either PI3KCA or AKT1 gene in the cases.ConclusionIn the present study we could not observe any mutation in PI3KCA and AKT1 gene, indicating that these mutations are rarely associated with endometriosis in South Indian women.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Nuclear Proteins Proto-Oncogene Proteins c-akt Transcription Factors Adult Case-Control Studies Endometriosis Endometriosis Exons Female Humans India India Mutation Nuclear Proteins Proto-Oncogene Proteins c-akt Risk Factors Transcription Factors Young Adult

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (36)

Cited by (3)

Source provenance

europepmc
last seen: 2026-09-04T06:17:57.233406+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:12.951333+00:00
unpaywall
last seen: 2026-09-04T06:34:25.427880+00:00
License: CC0 · commercial use OK