Meta-analysis of association between il-6-174 g/c polymorphism and female infertility related disorders

Benjamin JJ, Jiby Jolly Benjamin, Teena Koshy, Kumar KM, K. Mahesh Kumar, K N Maruthy, Maruthy KN, Padmavathi R, R. Padmavathi
Journal of Reproductive Immunology · 2020 · vol. 140 , pp. 103134 · doi:10.1016/j.jri.2020.103134 · PMID:32402924 · W3019083484
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This meta-analysis investigated the association between the IL-6-174 G/C polymorphism and female infertility related disorders, summarizing the current evidence on their link.

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Abstract

Female infertility continues to increase in prevalence annually and factors causing it need to be researched. As IL-6-174 G/C polymorphism is known to alter the plasma levels of IL-6, abnormal levels of IL-6 found in infertile females could be due to genetic reasons. With the understanding of the importance of IL-6 in reproductive physiology, several individual studies done so far to find the association of this polymorphism with female infertility related disorders were systematically combined for meta-analysis. Articles were searched using electronic data base sources and were included based on specific criteria. Finally, eight articles which includes polycystic ovarian syndrome (PCOS; n = 4), endometriosis (n = 3) and tubal damage (n = 1) were selected for the analysis. Results showed statistically significant heterogeneity across studies under the allele model (p < 0.0001, I2 = 78 %) and dominant model (p < 0.00001, I2 = 82%) but not under recessive model (p = 0.31, I2 = 16%). This difference could be possibly due to variation in ethnicity, lifestyle, age or BMI related factors. The pooled odds ratio under the three genetic models were 0.87(CI = 0.75-1.02), 0.77 (CI = 0.63-0.94) and 1.05 (CI = 0.76-1.46) respectively. Sub group analysis showed statistical significant (P < 0.01) for PCOS under allele and dominant model, but not for endometriosis and tubal damage. By this meta-analysis, we can say that IL-6-174 G/C polymorphism can be considered as a potential genetic marker for PCOS but not for endometriosis and tubal damage disorders. However, more studies with adequate sample sizes are required to be done in endometriosis, tubal disease and other female infertility disorders to arrive at a definite conclusion.

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Condition tags

infertility

MeSH descriptors

Infertility, Female Interleukin-6 Polycystic Ovary Syndrome Alleles Animals Female Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Infertility, Female Interleukin-6 Polycystic Ovary Syndrome Polymorphism, Genetic Pregnancy

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