Endometriose

In: Klinische Endokrinologie für Frauenärzte · 2024 · pp. 533–552 · doi:10.1007/978-3-662-65517-7_12 · W4393314005
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Endometriosis presents with diverse symptoms and is often underdiagnosed, but gynecologists can diagnose it using history, physical exam, and ultrasound.

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The paper describes endometriosis in a clinical-context overview, focusing on symptom presentation in women seen in everyday practice and discussing epidemiology, risk factors, and competing etiologic theories. It states that prevalence is uncertain but may be up to 30%, that diagnosis is often delayed despite strong symptoms, and that “thinking about it” could help reach diagnosis sooner; it also notes that diagnostic work-up is primarily in gynecologists’ hands using history, speculum and rectovaginal exams, and ultrasound, with additional tests only rarely needed. It emphasizes that treatment planning depends on the patient’s life situation, especially for those seeking children, requiring an overall concept considering multiple parameters. This paper is centrally about endometriosis — it provides an overview of clinical presentation, diagnostic approach, and treatment considerations for endometriosis.

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Zusammenfassung Patientinnen mit Endometriose präsentieren sich in der täglichen Praxis mit vielfältigen Symptomen. Die Erkrankung kann asymptomatisch bestehen oder mit starken Beschwerden assoziiert sein, oft stehen die Dysmenorrhö und der chronischer Unterbauchschmerz im Vordergrund. Die genaue Prävalenz ist unbekannt, dürfte aber bis zu 30 % betragen. Leider wird die Erkrankung trotz starker Beschwerden von nicht oder spät erkannt. Dabei wäre häufig ein „Drandenken“ ausreichend, um der Diagnose näher zu kommen. Die Definition von Risikofaktoren ist schwierig, einige scheinen aber zu bestehen und werden genannt. Auch die Entstehung von Endometriose ist nicht eindeutig geklärt, verschiedene Theorien existieren, werden weiterentwickelt und ergänzen sich gegenseitig. Die Diagnostik liegt mit einfachen Mitteln und Möglichkeiten eindeutig in den Händen der Gynäkologen, hierzu sind unsere Standarduntersuchungsverfahren meist ausreichend. Im Vordergrund stehen Anamnese, klinische Untersuchung mittels Spekulum, rektovaginale Untersuchung und die Sonografie. Selten werden Zusatzuntersuchungsverfahren nötig sein, sollten aber nicht ganz aus dem diagnostischen Repertoire verbannt werden. Insbesondere die Therapie ist von der Lebenssituation der Patientin abhängig und erfordert speziell bei Kinderwunschpatientinnen die Ausarbeitung eines Gesamtkonzepts unter Berücksichtigung aller Parameter. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others Literatur Adamson GD, Pasta DJ (2010) Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril 94:1609–1615 Aghaey Meibody F et al (2011) Diagnosis of endometrial nerve fibers in women with endometriosis. Arch Gynecol Obstet 284:1157–1162 Alhamdan D et al (2010) Mirena intra-uterine system: does it improve long term symptoms in women with chronic pelvic pain and/or endometriosis after laparoscopy? A multicentre randomized controlled trial. Rev Recent Clin Trials 5:143–146 Al-Jefout M et al (2009) Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double-blind study. Hum Reprod 24:3019–3024 Barcena de Arellano ML et al (2011) Influence of nerve growth factor in endometriosis-associated symptoms. Reprod Sci 18:1202–1210 Brosens I, Brosens JJ, Benagiano G (2012) The eutopic endometrium in endometriosis: are the changes of clinical significance? Reprod Biomed Online 24:496–502 Burghaus SKP, Fasching PA, Engel A et al (2012) Risk factors for endometriosis in a German Case-Control Study. Geburtsh Frauenheilkd 71:1073–1079 Cahill DJ (2002) What is the optimal medical management of infertility and minor endometriosis? Analysis and future prospects. Hum Reprod 17:1135–1140 Cahill DJ et al (1997) Ovarian dysfunction in endometriosis-associated and unexplained infertility. J Assist Reprod Genet 14:554–557 Candiani GB et al (1991) Reproductive and menstrual factors and risk of peritoneal and ovarian endometriosis. Fertil Steril 56:230–234 Chapron C et al (2011) Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis. Hum Reprod 26:2028–2035 D’Hooghe TM, Xiao L, Hill JA (2001) Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis. Arch Gynecol Obstet 265:40–44 Diagnosis and therapy of endometriosis. Guideline of the DGGG, SGGG and OEGGG (S2k-Level, AWMF Registry No. 045/015, August 2020). http://www.awmf.org/leitlinien/detail/ll/015-045.html Donnez J, Taylor HS, Stewart EA, Bradley L, Marsh E, Archer D, Al-Hendy A, Petraglia F, Watts N, Gotteland JP, Bestel E, Terrill P, Loumaye E, Humberstone A, Garner E (2022) Lancet 17;400(10356):896–907 Doody MC, Gibbons WE, Buttram VC Jr (1988) Linear regression analysis of ultrasound follicular growth series: evidence for an abnormality of follicular growth in endometriosis patients. Fertil Steril 49:47–51 Giudice LC et al (2022) Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2). Lancet 399(10343):2267–2279 and Supplementary Appendix Hassa H et al (2009) Cytokine and immune cell levels in peritoneal fluid and peripheral blood of women with early- and late-staged endometriosis. Arch Gynecol Obstet 279:891–895 Hudelist G, Fritzer N, Thomas A et al (2012) Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod 27:3412–3416 Keckstein J et al (2021) The #Enzian classification: a comprehensive non-invasive and surgical description system for endometriosis. Acta Obstet Gynecol Scand 100(7):1165–1175 Kennedy S et al (2005) ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 20:2698–2704 Khorram O et al (1993) Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis. Am J Obstet Gynecol 169:1545–1549 Knapp VJ (1999) How old is endometriosis? Late 17th- and 18th-century European descriptions of the disease. Fertil Steril 72:10–14 Kohler G et al (2010) A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis. Int J Gynaecol Obstet 108:21–25 Kunz G et al (2000) Structural abnormalities of the uterine wall in women with endometriosis and infertility visualized by vaginal sonography and magnetic resonance imaging. Hum Reprod 15:76–82 Leslie C, Ma T, McElhinney B et al (2013) Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis? Int J Gynecol Pathol 32:149–155 Leyendecker G et al (1996) Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility. Hum Reprod 11:1542–1551 Leyendecker G et al (1998) Endometriosis: a dysfunction and disease of the archimetra. Hum Reprod Update 4:752–762 Leyendecker G et al (2002) Endometriosis results from the dislocation of basal endometrium. Hum Reprod 17:2725–2736 Leyendecker G et al (2004) Uterine peristaltic activity and the development of endometriosis. Ann N Y Acad Sci 1034:338–355 Mahmood TA, Templeton A (1991) Prevalence and genesis of endometriosis. Hum Reprod 6:544–549 Mathur S, Garza DE, Smith LF (1990) Endometrial autoantigens eliciting immunoglobulin (Ig)G, IgA, and IgM responses in endometriosis. Fertil Steril 54:56–63 McLeod BS, Retzloff MG (2010) Epidemiology of endometriosis: an assessment of risk factors. Clin Obstet Gynecol 53:389–396 Meyer R (1919) Über den Stand der Frage der Adenomyositis, Adenomyome im Allgemeinen und insbesondere über Adenomyositis seroepithelialis und Adenomyometritis sarcomatosa. Zentralbl Gynäkol 36:745–750 Moen MH, Schei B (1997) Epidemiology of endometriosis in a Norwegian county. Acta Obstet Gynecol Scand 76:559–562 Nyholt DR et al (2012) Genome-wide association meta-analysis identifies new endometriosis risk loci. Nat Genet 44:1355–1359 Painter JN et al (2011) Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet 43:51–54 Petta CA, Ferriani RA, Abrao MS, Hassan D, Rosa E, Silva JC, Podgaec S, Bahamondes L (2005) Hum Reprod 20(7):1993–1998 Rousset-Jablonski C et al (2011) Catamenial pneumothorax and endometriosis-related pneumothorax: clinical features and risk factors. Hum Reprod 26:2322–2329 Sampson JA (1927) Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol 3:93–110 Schweppe KW (2003) Endometriose – Eine Erkrankung ohne Lobby. Zentralbl Gynäkol 125:233 Simon C et al (1994) Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 9:725–729 Sokolov DI et al (2005) Study of cytokine profile and angiogenic potential of peritoneal fluid in patients with external genital endometriosis. Bull Exp Biol Med 140:541–544 Strowitzki T et al (2010a) Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 151:193–198 Strowitzki T et al (2010b) Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Hum Reprod 25:633–641 Strowitzki T et al (2012) Detailed analysis of a randomized, multicenter, comparative trial of dienogest versus leuprolide acetate in endometriosis. Int J Gynaecol Obstet 117:228–233 Sukhikh GT et al (2004) Cytokine production by immunocompetent cells of peritoneal fluid in women with external genital endometriosis. Bull Exp Biol Med 137:568–571 Sundqvist J et al (2013) Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population. Hum Reprod 28:835–839 Treloar SA et al (2005) Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26. Am J Hum Genet 77:365–376 Tummon IS et al (1988) Occult ovulatory dysfunction in women with minimal endometriosis or unexplained infertility. Fertil Steril 50:716–720 Uno S et al (2010) A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet 42:707–710 Vigano P et al (2004) Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol 18:177–200 Wei DM et al (2011) [Relationship between endometriosis fertility index and pregnancies after laparoscopic surgery in endometriosis-associated infertility]. Zhonghua Fu Chan Ke Za Zhi 46:806–808 Xin L et al (2023) Efficacy and safety of oral gonadotropin-releasing hormone antagonists in moderate-to-severe endometriosis-associated pain: a systematic review and network meta-analysis. Arch Gynecol Obstet 2023 Jan 19 Xu H, Zhang MGC et al (2013) Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Angiogenesis 16:541–551 Yin X et al (2012) Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis. J Clin Endocrinol Metab 97:E35–E43 Zafrakas M et al (2008) Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: a high degree of differenziation rather than malignant potential. Int J Mol Med 21:335–344 Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2024 Der/die Autor(en), exklusiv lizenziert an Springer-Verlag GmbH, DE, ein Teil von Springer Nature About this chapter Cite this chapter Renner, S.P., Müller, A. (2024). Endometriose. In: Strowitzki, T., Ortmann, O. (eds) Klinische Endokrinologie für Frauenärzte. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65517-7_12 Download citation DOI: https://doi.org/10.1007/978-3-662-65517-7_12 Published: Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-662-65516-0 Online ISBN: 978-3-662-65517-7 eBook Packages: Medicine (German Language)

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