Diagnosis of endometrial nerve fibers in women with endometriosis

Fatemeh Aghaey Meibody, Abolfazl Mehdizadeh Kashi, Ali Zare Mirzaie, Marjan Ghajarie Bani Amam, Afsane Shariati Behbahani, Bita Zolali, Laily Najafi
Archives of gynecology and obstetrics · 2010 · vol. 284(5) , pp. 1157–1162 · doi:10.1007/s00404-010-1806-5 · PMID:21165744 · W1964378623
article OA: closed CC0 ⤵ 29 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Women with endometriosis had significantly higher nerve fiber density in endometrial biopsies compared to women without endometriosis, suggesting it is a reliable diagnostic marker.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated whether the density of small nerve fibers in endometrial tissue could serve as a diagnostic marker for endometriosis, using endometrial biopsies from women with pelvic pain and/or infertility scheduled for laparoscopy or laparotomy. Immunohistochemistry quantified protein gene product 9.5 and neurofilament in biopsies from 12 women with endometriosis and 15 without, finding that nerve fibers were present in all endometriosis cases but only in three women without endometriosis, with a much higher mean density in the endometriosis group (13.1 ± 3.3 vs 2.2 ± 4.7 mm−2; p < 0.001). The paper’s main limitation is the small sample size and relatively narrow comparison groups from a single clinical setting. This paper is centrally about endometriosis — it tests endometrial nerve fiber density as a diagnostic marker for endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Endometrium Adolescent Adult Biomarkers Biomarkers Biopsy Endometriosis Endometriosis Endometrium Endometrium Female Humans Infertility, Female Infertility, Female Middle Aged Nerve Fibers Nerve Fibers Neurofilament Proteins Neurofilament Proteins

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