Cytokine Production by Immunocompetent Cells of Peritoneal Fluid in Women with External Genital Endometriosis

Г. Т. Сухих, G T Sukhikh, N Yu Sotnikova, Yu S Antsiferova, Л. В. Посисеева, L V Posiseeva, V N Veryasov, Л. В. Ванько, L V Van'ko
Bulletin of experimental biology and medicine · 2004 · vol. 137(6) , pp. 568–571 · doi:10.1023/b:bebm.0000042714.32571.6b · PMID:15455087 · W2083257986
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Endometriosis alters peritoneal fluid immune cell ratios and increases IL-1β, TNF-α, and EGF levels in peritoneal fluid and macrophage cultures, while IFN-γ increases in lymphocyte cultures.

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Abstract

The content of some cytokines in the peritoneal fluid and the level of their in vitro production by peritoneal macrophages and lymphocytes were evaluated in women with external endometriosis. The ratio of peritoneal lymphocytes and macrophages in the peritoneal fluid was changed in endometriosis because of increased percentage of lymphoid cells and decreased content of macrophages, in the presence of high absolute counts of both types of cells. The cytokine status of women with endometriosis was characterized by higher levels of IL-1β, TNF-α, and epidermal growth factors both in the peritoneal fluid and supernatants of 24-h cultures of peritoneal macrophages; the content of IFN-α remained unchanged. The concentrations of IFN-γ in the peritoneal fluid did not change in endometriosis, but increased in the supernatants of peritoneal lymphocyte cultures. Similar content being viewed by others

References

L. V. Adamyan and V. I. Kulakov, Endometriosis. Manual for Physicians [in Russian], Moscow (1998). D. V. Kuyavskaya, K. V. Grigoryan, S. F. Torubarov, and G. T. Sukhikh, Probl. Reprod., 5, No. 2, 62-44 (1999). A. Akoum, A. Lemay, S. McColl, et al., Fertil. Steril., 66, No. 1, 17-23 (1996). J. L. Becker, R. H. Widen, C. S. Mahan, et al., J. Reprod. Immunol., 34, No. 3, 179-187 (1995). J. Halme, S. Becker, and S. Haskill, Am. J. Obstet. Gynecol., 156, No. 4, 783-789 (1987). T. Harada, T. Iwabe, and N. Terakawa, Fertil. Steril., 76, No. 1, 1-10 (2001). H. N. Ho, M. Y. Wu, K. H. Chao, et al., Hum. Reprod., 12, No. 11, 2528-2533 (1997). H. N. Ho, M. Y. Wu, and Y. S. Yang, Am. J. Reprod. Immunol., 38, No. 6, 400-412 (1997). T. Iwabe, T. Harada, T. Tsudo, et al., Fertil. Steril., 69, No. 5, 924-930 (1998). J. A. Keenan, T. T. Chen, N. L. Chadwell, et al., Am. J. Reprod. Immunol., 32, 180-183 (1994). J. A. Keenan, T. T. Chen, N. L. Chadwell, et al., Ibid., 34, No. 6, 381-385 (1995). B. S. Lee, E. A. Stewart, M. Sahakian, and R. A. Nowak, Ibid., 65, 19-25 (1998). J. McLaren, Hum. Reprod., 6, 45-55 (2000). H. Mori, M. Sawairi, M. Nakagawa, et al., Am. J. Reprod. Immunol., 26, No. 2, 62-67 (1991). M. Y. Wu, H. N. Ho, S. U. Chen, et al., Ibid., 41, No. 1, 106-111 (1999). Author information Authors and Affiliations Rights and permissions About this article Cite this article Sukhikh, G.T., Sotnikova, N.Y., Antsiferova, Y.S. et al. Cytokine Production by Immunocompetent Cells of Peritoneal Fluid in Women with External Genital Endometriosis. Bulletin of Experimental Biology and Medicine 137, 568–571 (2004). https://doi.org/10.1023/B:BEBM.0000042714.32571.6b Issue date: DOI: https://doi.org/10.1023/B:BEBM.0000042714.32571.6b

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cytokines Endometriosis Lymphocytes Macrophages, Peritoneal Ascitic Fluid Ascitic Fluid Ascitic Fluid Cells, Cultured Cytokines Endometriosis Endometriosis Female Humans Lymphocytes Lymphocytes Macrophages, Peritoneal Macrophages, Peritoneal

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