Cytokine Production by Immunocompetent Cells of Peritoneal Fluid in Women with External Genital Endometriosis

Г. Т. Сухих, G T Sukhikh, Sukhikh GT, N Yu Sotnikova, Yu S Antsiferova, Antsiferova YS, Л. В. Посисеева, L V Posiseeva, V N Veryasov, Veryasov VN, Van'ko LV, Л. В. Ванько, L V Van'ko
Bulletin of experimental biology and medicine · 2004 · vol. 137(6) , pp. 568–571 · doi:10.1023/b:bebm.0000042714.32571.6b · PMID:15455087 · W2083257986
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Women with external endometriosis exhibit altered peritoneal fluid immune cell ratios and increased IL-1β, TNF-α, and EGF levels, with enhanced IFN-γ production by lymphocytes.

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The study evaluated cytokine content in peritoneal fluid and the in vitro cytokine production of peritoneal macrophages and lymphocytes in women with external genital endometriosis. It found that the relative proportions of peritoneal immune cells shifted, with increased lymphoid cell percentage and decreased macrophage content despite high absolute counts of both cell types, and that endometriosis was associated with higher IL-1β, TNF-α, and epidermal growth factor levels in peritoneal fluid and in 24-hour macrophage culture supernatants, while IFN-α remained unchanged. IFN-γ concentrations were not altered in peritoneal fluid but increased in supernatants from lymphocyte cultures. The paper does not explicitly state additional limitations in the provided text. This paper is centrally about endometriosis — it characterizes peritoneal cytokine production by macrophages and lymphocytes in women with external genital endometriosis.

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Abstract

The content of some cytokines in the peritoneal fluid and the level of their in vitro production by peritoneal macrophages and lymphocytes were evaluated in women with external endometriosis. The ratio of peritoneal lymphocytes and macrophages in the peritoneal fluid was changed in endometriosis because of increased percentage of lymphoid cells and decreased content of macrophages, in the presence of high absolute counts of both types of cells. The cytokine status of women with endometriosis was characterized by higher levels of IL-1beta, TNF-alpha, and epidermal growth factors both in the peritoneal fluid and supernatants of 24-h cultures of peritoneal macrophages; the content of IFN-alpha remained unchanged. The concentrations of IFN-gamma in the peritoneal fluid did not change in endometriosis, but increased in the supernatants of peritoneal lymphocyte cultures.
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Abstract

The content of some cytokines in the peritoneal fluid and the level of their in vitro production by peritoneal macrophages and lymphocytes were evaluated in women with external endometriosis. The ratio of peritoneal lymphocytes and macrophages in the peritoneal fluid was changed in endometriosis because of increased percentage of lymphoid cells and decreased content of macrophages, in the presence of high absolute counts of both types of cells. The cytokine status of women with endometriosis was characterized by higher levels of IL-1β, TNF-α, and epidermal growth factors both in the peritoneal fluid and supernatants of 24-h cultures of peritoneal macrophages; the content of IFN-α remained unchanged. The concentrations of IFN-γ in the peritoneal fluid did not change in endometriosis, but increased in the supernatants of peritoneal lymphocyte cultures. Similar content being viewed by others

References

L. V. Adamyan and V. I. Kulakov, Endometriosis. Manual for Physicians [in Russian], Moscow (1998). D. V. Kuyavskaya, K. V. Grigoryan, S. F. Torubarov, and G. T. Sukhikh, Probl. Reprod., 5, No. 2, 62-44 (1999). A. Akoum, A. Lemay, S. McColl, et al., Fertil. Steril., 66, No. 1, 17-23 (1996). J. L. Becker, R. H. Widen, C. S. Mahan, et al., J. Reprod. Immunol., 34, No. 3, 179-187 (1995). J. Halme, S. Becker, and S. Haskill, Am. J. Obstet. Gynecol., 156, No. 4, 783-789 (1987). T. Harada, T. Iwabe, and N. Terakawa, Fertil. Steril., 76, No. 1, 1-10 (2001). H. N. Ho, M. Y. Wu, K. H. Chao, et al., Hum. Reprod., 12, No. 11, 2528-2533 (1997). H. N. Ho, M. Y. Wu, and Y. S. Yang, Am. J. Reprod. Immunol., 38, No. 6, 400-412 (1997). T. Iwabe, T. Harada, T. Tsudo, et al., Fertil. Steril., 69, No. 5, 924-930 (1998). J. A. Keenan, T. T. Chen, N. L. Chadwell, et al., Am. J. Reprod. Immunol., 32, 180-183 (1994). J. A. Keenan, T. T. Chen, N. L. Chadwell, et al., Ibid., 34, No. 6, 381-385 (1995). B. S. Lee, E. A. Stewart, M. Sahakian, and R. A. Nowak, Ibid., 65, 19-25 (1998). J. McLaren, Hum. Reprod., 6, 45-55 (2000). H. Mori, M. Sawairi, M. Nakagawa, et al., Am. J. Reprod. Immunol., 26, No. 2, 62-67 (1991). M. Y. Wu, H. N. Ho, S. U. Chen, et al., Ibid., 41, No. 1, 106-111 (1999). Author information Authors and Affiliations Rights and permissions About this article Cite this article Sukhikh, G.T., Sotnikova, N.Y., Antsiferova, Y.S. et al. Cytokine Production by Immunocompetent Cells of Peritoneal Fluid in Women with External Genital Endometriosis. Bulletin of Experimental Biology and Medicine 137, 568–571 (2004). https://doi.org/10.1023/B:BEBM.0000042714.32571.6b Issue date: DOI: https://doi.org/10.1023/B:BEBM.0000042714.32571.6b

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Lymphocytes Macrophages, Peritoneal Ascitic Fluid Ascitic Fluid Ascitic Fluid Cells, Cultured Cytokines Endometriosis Endometriosis Female Humans Lymphocytes Lymphocytes Macrophages, Peritoneal Macrophages, Peritoneal

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