N. Yu. Sotnikova

Endometriosis is a chronic disease with a steady upward trend in the frequency of occurrence among the women of reproductive age, often in severe form, with relapses of the disease and resistance to therapy. Endometriosius has an impact on …

OBJECTIVE: To establish the relationship between the endometrial apoptosis parameters and endometrial receptivity in infertile women undergoing IVF treatment. METHODS: 73 women with tubal infertility, 27 infertile women with endometriosis a…

The aim of the present work was to compare in vitro the possibility of application of unmodified silica nanoparticles (UMNPs) and modified by aminopropyl groups silica nanoparticles (AMNPs) for topical delivery of immunomodulatory drug GMDP…

Taking into account all evidential results relating to low toxicity of APTES-modified and unmodified silica nanoparticles with a radius of 50 nm, its intensive interaction with the peritoneal macrophages, as well as the absence of the prono…

OBJECTIVE: To compare the expression of MMP-2, TIMP-2, and TGFbeta2 mRNA in experimental and human endometriotic lesions and to assess the possibility of its cytokine regulation. DESIGN: Experimental laboratory study. SETTING: Medical cen…

ObjectiveTo estimate regulatory cytokine synthesis and lymphocyte activation in the peripheral blood and endometrial tissue of patients with endometriosis.DesignControlled clinical study.SettingMedical center.Patient(s)Fifteen women with la…

The content of some cytokines in the peritoneal fluid and the level of their in vitro production by peritoneal macrophages and lymphocytes were evaluated in women with external endometriosis. The ratio of peritoneal lymphocytes and macropha…

PROBLEM: Recent studies showed the impairment of local cytokine balance in women with external endometriosis, but similar findings concerning direct production of cytokines by immunocompetent cells of women with adenomyosis are absent. In t…

The aim of our work was to establish the peculiarities of phenotype profile and functional activity of peritoneal immunocompetent cells of women with different rate of myoma growth. Forty three women with uterine myoma (main group) and 16 h…

The aim of the study was to elucidate the role of epidermal growth factor (EGF) in pathogenesis of endometriosis at different stages of disease. The level of EGF in peritoneal fluid (PF) of fertile and infertile women with endometriosis and…

The aim of the study was to elucidate the role of epidermal growth factor (EGF) in pathogenesis of endometriosis at different stages of disease. The level of EGF in peritoneal fluid (PF) of fertile and infertile women with endometriosis and…

The aim of the present investigation was to study the peculiarities of peritoneal lymphoid cell activation at the local level during external endometriosis and the possible role of secretory products of peritoneal macrophages in this proces…