Inhibition of human endometrial stromal cell proliferation by interleukin 6
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Interleukin 6 (IL-6) dose-dependently inhibited human endometrial stromal cell proliferation in vitro, indicating IL-6's role in endometrial growth regulation.
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Abstract
We investigated the ability of interleukin 6 (IL-6) to modulate human endometrial stromal cell growth in vitro. Stromal cell proliferation in response to treatment with varying concentrations of IL-6 was determined. Endometrial tissue was obtained from 10 normally cycling women during the secretory phase of their menstrual cycle. Treatment with IL-6 resulted in a dose- and cell-density-dependent inhibition of endometrial stromal cell proliferation in vitro. The maximal inhibition was observed with 200 pg/ml of IL-6 and at a concentration of 10(5) cells/well. During in-vitro culture, stromal cells produced low amounts of IL-6 and demonstrated the presence of IL-6 receptor. These data demonstrate that IL-6 acts as a growth-regulatory signal for human endometrial stromal cells. We postulate that IL-6 may contribute to the maintenance of homeostasis in normal endometrium and that perturbation of IL-6 mediated responses may play a role in disorders of the endometrium such as endometrial cancer and endometriosis.
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Cited by (36)
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- The Role of the Immune System in the Development of Endometriosis 2022
- Non-invasive diagnosis of endometriosis: Immunologic and genetic markers 2022
- The role of the immune system in the pathogenesis of endometriosis 2021
- Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy 2020
- Immunology of endometriosis 2018
- Role of Interleukin-6 and Its Receptor in Endometriosis 2017
- Inflammation and Endometriosis 2011
- Efeitos do sistema intra-uterino de Levonorgestrel sobre marcadores de risco cardiovascular de pacientes com endometriose: estudo comparativo com o análogo do GnRH 2009
- Biomarkers of endometriosis 2008
- Resolving endometriosis-induced pain utilizing a low-glycemic diet 2008
- Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis 2008
- Inflammatory status influences aromatase and steroid receptor expression in endometriosis 2007
- Altered apoptosis and proliferation in endometrial stromal cells of women with adenomyosis 2007
- Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: a possible role for PCBs and DDE 2006
- Proinflammatory cytokines IL-1β , IL-8 and IL-6 in the follicular fluid of healthy women 2004
- Serum and cyst fluid levels of interleukin (IL) -6, IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours 2003
- Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells 2003
- The role of cytokines in endometriosis 2003
- Endometriosis is associated with alterations in the relative abundance of proteins and IL-10 in the peritoneal fluid 2003
- Immunology of endometriosis 2002
- Cytokine profiles in autologous peritoneal fluid and peripheral blood of women with deep and superficial endometriosis 2001
- Immunobiology of endometriosis 2001
- Expression of the cyclin-dependent kinase inhibitor p27Kip1 in eutopic endometrium and peritoneal endometriosis 2001
- Interleukin 1beta, interleukin-6, and tumor necrosis factor-alpha in endometriotic tissue and in endometrium 2001
- Altered gene expression and secretion of interleukin-6 in stromal cells derived from endometriotic tissues 2000
- Production of interleukins 1beta, 6 and 8 and tumor necrosis factor alpha in separated and cultured endometrial and endometriotic stromal and epithelial cells 2000
- Retinoic acid suppresses interleukin-6 production in human endometrial cells 2000
- Current concepts in the pathogenesis of endometriosis 1999
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
- Immunology and endometriosis. Fact, artifact, or epiphenomenon? 1997
- Angiogenesis and macrophage activation in endometriosis 1997
- Immunological aspects of endometriosis 1996
- Characterization of lymphocyte subpopulations and T cell activation in endometriosis 1994
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