The role of peroxisome proliferator-activated receptors in endometriosis

Iason Psilopatis, Stamatios Theocharis, Matthias W Beckmann
Frontiers in medicine · 2024 · vol. 11 , pp. 1329406 · doi:10.3389/fmed.2024.1329406 · PMID:38690174 · PMC11058831 · W4394850309
review OA: gold CC0 ⤵ 3 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This literature review found that PPARs, particularly PPARγ, are involved in endometriosis pathophysiology and that targeting the PPAR system offers potential therapeutic options for the disease.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper is a narrative literature review examining the role of peroxisome proliferator-activated receptors (PPARs) in endometriosis pathophysiology, using MEDLINE and LIVIVO searches (2001–2022) and selecting 36 relevant original research articles/abstracts after full-text screening, while excluding studies focused on uterine fibroids or endometrial cancer. It summarizes evidence that PPAR signaling—especially PPARγ—has been linked to pathways involved in disease onset and progression, and discusses mechanistic findings including PPARα and PPARγ expression in peritoneal macrophages and stage-dependent changes in PPARα reporter activation by endometriosis patient peritoneal fluid; one stated limitation is that the paper is a literature review rather than new experimental work. It also highlights data implicating PPARα in processes such as cholesterol accumulation/estrogen production, as well as mouse findings in surgically induced endometriosis where PPARα deficiency was associated with impaired angiogenesis and altered inflammation. This paper is centrally about endometriosis—specifically how PPAR signaling (PPARα/γ and related pathways) may contribute to endometriosis pathophysiology and potential therapeutic targeting.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis constitutes the most common cause of chronic pelvic pain in female patients and is associated with infertility. Although there is no known cause for the disease, it is a heritable condition that is determined by numerous genetic, epigenetic, and environmental aspects. Peroxisome proliferator-activated receptors (PPARs) represent nuclear receptor proteins that control gene expression. By using the MEDLINE and LIVIVO databases we conducted a literature review in order to look into the role of PPARs in the endometriosis pathophysiology and succeeded in revealing 36 pertinent publications between 2001 and 2022. In regards to PPAR expression in endometriosis, PPARγ seems to represent the most studied PPAR isoform in endometriosis and to influence various pathways involved in the disease onset and progression. It's interesting to note that diverse treatment agents targeting the PPAR system have been identified as innovative, effective therapeutic alternatives in the context of endometriosis treatment. In conclusion, PPARs appear to contribute an important role in both endometriosis pathophysiology and therapy.

My notes (saved in your browser only)

Condition tags

endometriosischronic_pelvic_paininfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (93)

Cited by (3)

Source provenance

europepmc
last seen: 2026-06-12T06:13:51.797165+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-06-12T06:11:54.446292+00:00
License: CC0 · commercial use OK