Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis

Jean‐Christophe Noël, Jean-Christophe Noël, Noël JC, Chapron C, Charles Chapron, Bucella D, Dario Bucella, Frederic Buxant, Buxant F, Frédéric Buxant, Peny MO, Marie-Odile Peny, Fayt I, Isabelle Fayt, Bruno Borghese, Borghese B, Vincent Anaf, Anaf V
Fertility and sterility · 2009 · vol. 93(6) , pp. 1774–1777 · doi:10.1016/j.fertnstert.2008.12.114 · PMID:19217090 · W1982532500
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This paper investigated the presence and distribution of estrogen and progesterone receptors within the smooth muscle of deep infiltrating endometriosis lesions.

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Abstract

ObjectiveTo analyze the expression of estrogen (ER) and progesterone (PR) receptors in the smooth muscle component (SMC) of deep infiltrating endometriosis (DIE).DesignA prospective clinical and pathologic study of 60 cases of DIE.SettingUniversity Hospital Department of Gynacology.Patient(s)Sixty patients with symptomatic DIE (uterosacral endometriosis n = 14; bladder endometriosis n = 10; colonic endometriosis n = 16; rectovaginal endometriosis n = 20).Intervention(s)Laparoscopic surgery.Main outcome measure(s)The expression of ER and PR was studied by immunohistochemistry in the SMC directly around endometriotic foci and at distance (at least >1.5 cm) from them in correlation with proliferative and secretory phases of cycle.ResultsThe ER and PR were present in the SMC of DEI in each location excepting colonic endometriosis where ER were absent. Independently of cycle's phases the PR were more abundant than ER. With the exception of rectovaginal endometriosis, where the ER and PR were more abundant in the proliferative than in the secretory phase, in other locations the ER and PR did not differ significantly with cycle's phases. Last, if ER and PR were more abundant in SMC around endometriotic foci than at a distance from them. However, the difference was not significant.ConclusionsOur data substantially confirm for the first time that in various forms of DIE, ER and PR are present not only in glands and stroma but also in the smooth muscle major histologic component of this disease.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Intestinal Diseases Muscle, Smooth Receptors, Estrogen Receptors, Progesterone Urinary Bladder Diseases Endometriosis Endometriosis Female Follicular Phase Follicular Phase Humans Intestinal Diseases Intestinal Diseases Luteal Phase Luteal Phase Muscle, Smooth Muscle, Smooth Receptors, Estrogen Receptors, Progesterone

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