The steroidogenic factor-1 protein is not expressed in various forms of endometriosis but is strongly present in ovarian cortical or medullary mesenchymatous cells adjacent to endometriotic foci

Jean-Christophe Noël, Noël JC, Jean‐Christophe Noël, Anaf V, Vincent Anaf, Borghese B, Bruno Borghese, Daniel Vaiman, Fayt I, Isabelle Fayt, Chapron C, Charles Chapron
Fertility and sterility · 2011 · vol. 95(8) , pp. 2655–2657 · doi:10.1016/j.fertnstert.2011.01.131 · PMID:21324456 · W1975122537
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Steroidogenic factor-1 protein was not detected in various forms of endometriosis but was strongly present in ovarian mesenchymatous cells near endometriotic lesions.

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Abstract

Steroidogenic factor-1 (SF-1) protein expression was not observed in any form of endometriosis (peritoneal, ovarian, or deep infiltrating endometriosis), which suggests that SF-1 locally produced by endometrial or stromal cells may not play a major role in the development of endometriosis. However, the strong expression of SF-1 in cortical and medullary ovarian mesenchymatous cells may be capable of creating a favorable steroidogenic environment and the development of the disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Mesoderm Ovarian Diseases Ovary Peritoneal Diseases Steroidogenic Factor 1 Stromal Cells Biopsy Case-Control Studies Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunohistochemistry Mesoderm Mesoderm Ovarian Diseases

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