Expression of Estrogen and Progesterone Receptors in Smooth Muscle Metaplasia of Rectovaginal Endometriosis

Kitano T, Takamitsu Kitano, Toshiharu Matsumoto, Matsumoto T, Takeuchi H, Hiroyuki Takeuchi, Iwaho Kikuchi, Itoga T, Tomoko Itoga, Noriko Sasahara, Sasahara N, Katsuyuki Kinoshita, Kinoshita K
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2007 · vol. 26(2) , pp. 124–129 · doi:10.1097/01.pgp.0000235067.16054.dd · PMID:17413977 · W2016800879
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Estrogen and progesterone receptors were found in smooth muscle cells of smooth muscle metaplasia outside rectovaginal endometriosis foci, with lower expression in the GnRH agonist group.

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Abstract

To investigate expression of estrogen receptors (ER) and progesterone receptors (PR) in smooth muscle metaplasia (SMM) outside the endometriotic foci of rectovaginal endometriosis (RVE). One hundred and ninety-five specimens were obtained from the rectovaginal areas of the 63 patients who were underwent laparoscopic surgery for RVE. The patients were divided into 3 groups: a gonadotropin-releasing hormone (GnRH) agonist group, a non-GnRH group, including a proliferative phase group, and a secretory phase group. Expression of ER and PR in the rectovaginal tissues of RVE were determined using immunohistochemical methods. Smooth muscle metaplasia occurred in 172 specimens (88.2%), and ER and PR expression were found in the smooth muscle cells in the SMM areas outside the endometriotic foci of RVE. The expression of ER and PR in the GnRH agonist group were significantly lower than those in the non-GnRH agonist group. This is the first report demonstrating ER and PR in the smooth muscle cells in SMM outside the endometriotic foci of RVE. The ER and PR were expressed in the SMM areas, but these receptors were not recognized in fibrotic areas. We could identify the expression ratio of these receptors during each menstrual phase, with or without administered GnRH agonist.
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Expression of Estrogen and Progesterone Receptors in Smooth Muscle Metaplasia of Rectovaginal Endometriosis - Takamitsu Kitano - Toshiharu Matsumoto - Hiroyuki Takeuchi - Iwaho Kikuchi - Tomoko Itoga - Noriko Sasahara - Katsuyuki Kinoshita Summary: To investigate expression of estrogen receptors (ER) and progesterone receptors (PR) in smooth muscle metaplasia (SMM) outside the endometriotic foci of rectovaginal endometriosis (RVE). One hundred and ninety-five specimens were obtained from the rectovaginal areas of the 63 patients who were underwent laparoscopic surgery for RVE. The patients were divided into 3 groups: a gonadotropin-releasing hormone (GnRH) agonist group, a non-GnRH group, including a proliferative phase group, and a secretory phase group. Expression of ER and PR in the rectovaginal tissues of RVE were determined using immunohistochemical methods. Smooth muscle metaplasia occurred in 172 specimens (88.2%), and ER and PR expression were found in the smooth muscle cells in the SMM areas outside the endometriotic foci of RVE. The expression of ER and PR in the GnRH agonist group were significantly lower than those in the non-GnRH agonist group. This is the first report demonstrating ER and PR in the smooth muscle cells in SMM outside the endometriotic foci of RVE. The ER and PR were expressed in the SMM areas, but these receptors were not recognized in fibrotic areas. We could identify the expression ratio of these receptors during each menstrual phase, with or without administered GnRH agonist.

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Condition tags

endometriosisbowel_endometriosis

MeSH descriptors

Endometriosis Muscle, Smooth Receptors, Estrogen Receptors, Progesterone Rectum Vagina Adult Endometriosis Endometriosis Endometriosis Female Fibrosis Fibrosis Fibrosis Gene Expression Regulation Gene Expression Regulation Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans

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