Malignant Transformation of Pelvic Endometriosis: Case Series and Review of the Literature

Sunil Jaiman, Pochiraju M, Manjula Pochiraju, Sirisha Rao Gundabattula, Surampudi K, Kameswari Surampudi, Narayana Rao DV, Dama Venkata Lakshmi Narayana Rao, Sreekanth Kandikattu, Kandikattu S
International journal of surgical pathology · 2015 · vol. 23(6) , pp. 465–471 · doi:10.1177/1066896915583995 · PMID:25911569 · W2165472884
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This paper reports on three premenopausal women who developed endometrioid adenocarcinoma from endometriosis, highlighting that malignancy is often unsuspected preoperatively despite the presence of endometriosis.

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Abstract

Endometriosis affects 4% to 13% of all women of reproductive age although its true incidence is unknown. The ability of endometriosis to transform into malignancy, first described by Sampson in 1925, is a rare occurrence affecting 1% of lesions with ovary being the primary site in 79%. The authors describe 3 premenopausal women without risk factors for malignancy presenting with ovarian and/or extraovarian endometrioid adenocarcinoma. All of them demonstrated features of pre-/coexisting endometriosis but malignancy was preoperatively suspected in only 1 instance. Postsurgical follow-up of the cases did not document any recurrence. The propensity for malignant conversion occurring in women 10 to 20 years younger vis-a-vis those affected by de novo ovarian cancer, destruction of the endometriotic foci, and underreporting vindicate close follow-up and scrutiny of women with endometriosis and ovarian endometriomas.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Endometriosis Ovarian Neoplasms Precancerous Conditions Adult Adult Carcinoma, Endometrioid Carcinoma, Endometrioid Endometriosis Endometriosis Female Female Humans Humans Middle Aged Middle Aged Ovarian Diseases Ovarian Diseases Ovarian Diseases Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (34)

Cited by (10)

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License: CC0 · commercial use OK