Intractable primary infertility in women exposed to diethylstilbestrol in utero.
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Primary infertility was more frequent and conception rates lower in women exposed to diethylstilbestrol in utero, particularly those with uterine deformities.
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Abstract
Fertility factors were examined in 50 women with primary infertility and presumed in utero diethylstilbestrol (DES) exposure and in 50 age-matched controls. Uterine deformities and endometriosis were more frequent in the DES-exposed women than the controls. When managed from one to four years, only 4% of DES-exposed women with primary infertility conceived (with no conceptions resulting in a viable fetus) as compared to 44% of controls. Primary infertility of one to two years' duration with uterine deformities characteristic of DES exposure seems to signal a poor prognosis for pregnancy despite treatment of identifiable fertility factors.
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Cited by (8)
- Early-life factors, in-utero exposures and endometriosis risk: a meta-analysis 2020
- Endometriosis 2017
- <i>In utero</i> exposure and endometriosis 2013
- Sources of heterogeneities in estimating the prevalence of endometriosis in infertile and previously fertile women 2006
- In utero exposures and the incidence of endometriosis 2004
- New considerations for the pathogenesis of endometriosis 2002
- Effect of in-utero diethylstilboestrol exposure on human oocyte quality and fertilization in a programme of in-vitro fertilization 1999
- EPIDEMIOLOGY OF ENDOMETRIOSIS 1997
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- openalex
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- pubmed
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