Number needed to freeze: cumulative live birth rate after fertility preservation in women with endometriosis

Ana Cobo, Cobo A, Aila Coello, Coello A, de Los Santos MJ, María José de los Santos, Giles J, Juan Giles, Juan Gilés, Pellicer A, António Pellicer, Antonio Pellicer, Remohí J, José Remohı́, José Remohí, García-Velasco JA, Juan A. García-Velasco
Reproductive BioMedicine Online · 2021 · vol. 42(4) , pp. 725–732 · doi:10.1016/j.rbmo.2020.12.013 · PMID:33573907 · W3119183313
article OA: green CC0 ⤵ 16 in-corpus citations
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This study calculated the number of women with endometriosis who needed to undergo fertility preservation to achieve one cumulative live birth.

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Abstract

Research questionHow does the number of oocytes used affect the cumulative live birth rate (CLBR) in endometriosis patients who had their oocytes vitrified for fertility preservation?DesignRetrospective observational study including data from 485 women with endometriosis who underwent fertility preservation from January 2007 to July 2018. Survival curves and Kaplan-Meier plots were used to analyse the CLBR according to the number of vitrified oocytes used. Endometriosis curves were compared with plots developed using elective fertility preservation (EFP) patients as control group. Log-rank, Breslow and Tarone-Ware tests were used to compare the survival curves.ResultsThe CLBR increased as the number of oocytes used per patient rose, reaching 89.5% (95% confidence interval [CI] 80.0-99.1%) using 22 oocytes. Higher outcomes were observed in young women (≤35 years old versus >35 years old). In the younger group, the CLBR was 95.4% (95% CI 87.2-103.6%) using approximately 20 oocytes versus 79.6% (95% CI 58.1-101.1%) in older women (log-rank [Mantel-Cox] P = 0.002). The mean age was higher in EFP patients (37.2 ± 4.9 versus 35.7 ± 3.7; P < 0.001). The outcome was better in the endometriosis group as compared with EFP: a CLBR of 89.5% (95% CI 80.0-99.1%) versus 59.9% (95% CI 51.4-68.6%) when 22 oocytes were used (log-rank [Mantel-Cox] P < 0.00001).ConclusionThe probability of live birth increases as the number of oocytes used increases in patients with endometriosis, but better outcomes were observed among young women. The information provided here may be of interest to both patients and treating physicians for counselling purposes.
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Condition tags

endometriosis

MeSH descriptors

Birth Rate Endometriosis Fertility Preservation Oocytes Adult Female Fertility Preservation Humans Pregnancy Retrospective Studies

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

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License: CC0 · commercial use OK