T allele for VEGF gene-460 polymorphism at the 5'-untranslated region: association with a higher susceptibility to endometriosis.

Yao‐Yuan Hsieh, Hsieh YY, Yao-Yuan Hsieh, Chang CC, Chi-Chen Chang, Fuu‐Jen Tsai, Tsai FJ, Fuu-Jen Tsai, Yeh LS, Lian-Shun Yeh, Lin CC, Cheng‐Chieh Lin, Cheng-Chieh Lin, Peng CT, Ching-Tien Peng
The Journal of reproductive medicine · 2004 · vol. 49(6) , pp. 468–72 · PMID:15283056 · W1702739804
article OA: closed CC0 ⤵ 31 in-corpus citations
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The T allele and T/T homozygotes for the VEGF gene-460 polymorphism are associated with a higher risk of endometriosis, while heterozygotes and the C allele are related to a lower risk.

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Abstract

OBJECTIVE: To investigate whether vascular endothelial growth factor (VEGF) gene 5'-UTR-460 polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 122) and nonendometriosis (n = 131). Polymorphisms for VEGF were detected by polymerase chain reaction and BstUI (New England Biolabs, Beverly, Massachusetts) restriction enzyme analysis. Genotypes and allelic frequencies between the groups were compared. RESULTS: Proportions of different VEGF polymorphisms in the groups were significantly different. Proportions of cuttable (C) homozygote/heterozygote/ uncuttable (T) homozygotefor VEGF in the groups were 0/44.3/55.7% and 0/63.4/36.6%, respectively. A higher percentage of T/F homozygote and T allele was present in the endometriosis population. The proportions of C/T alleles in the groups were 22.1/77.9% and 31.7/68.3%, respectively. CONCLUSION: T/T homozygotes and the T allele of the VEGF-460 gene are associated with a higher risk of endometriosis. Heterozygotes and C allele are related to the lower risk of endometriosis formation. VEGF polymorphism likely contributes to the pathogenesis of endometriosis and may become a useful markerfor predicting endometriosis susceptibility.

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Condition tags

endometriosis

MeSH descriptors

5' Untranslated Regions Endometriosis Genetic Predisposition to Disease Polymorphism, Genetic Vascular Endothelial Growth Factor A Adult Case-Control Studies Endometriosis Female Genotype Humans Polymerase Chain Reaction Premenopause Vascular Endothelial Growth Factor A

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