Increased nitric oxide in peritoneal fluid from women with idiopathic infertility and endometriosis.
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Peritoneal fluid concentrations of nitric oxide metabolites were significantly increased in women with idiopathic infertility and endometriosis compared to controls.
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Abstract
OBJECTIVE: To verify whether nitric oxide in peritoneal fluid is associated with endometriosis and infertility. STUDY DESIGN: Twenty-five women with idiopathic infertility and 38 with endometriosis were recruited, and 18 cases of uterine myomata and 2 cases of ovarian cyst served as controls. Peritoneal fluid samples were aspirated from the pouch of Douglas during laparoscopy or laparotomy. Metabolites of nitric oxide (nitrite and nitrate) in peritoneal fluid were determined by a method using nitrate reductase and the Griess reaction. RESULTS: Peritoneal concentrations of nitrate/nitrite in both infertile women (42.02 +/- 12.98 mmol/L) and patients with endometriosis (41.75 +/- 16.42 mmol/L) were significantly higher than that in controls (33.96 +/- 13.07, P .5). Peritoneal levels of nitrate/nitrite were comparable among patients with endometriosis at different stages (P > .5). Patients with endometriosis had more peritoneal fluid than controls and idiopathic infertile women, while controls and idiopathic infertile women had comparable amounts of peritoneal fluid. CONCLUSION: An increased peritoneal level of nitric oxide is a common alteration in endometriosis, endometriosis-associated infertility and idiopathic infertility and may be associated with the pathogenesis of these diseases.
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Cited by (22)
- The Pathological Role of miRNAs in Endometriosis 2023
- Clotrimazole is effective, safe and tolerable for the treatment of endometriosis and functions by downregulating inducible nitric oxide synthase and modulating oxidative stress biomarkers 2023
- Oxidative stress-related effects on various aspects of endometriosis 2022
- Oxidative stress-related effects on various aspects of endometriosis 2022
- Antioxidants in Female Reproductive Biology 2021
- Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile 2018
- Asymmetric dimethylarginine (ADMA), nitric oxide metabolite, and estradiol levels in serum and peritoneal fluid in women with endometriosis 2015
- Role of iron overload-induced macrophage apoptosis in the pathogenesis of peritoneal endometriosis 2014
- Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis 2013
- The Effect of Peritoneal Fluid from Patients with Endometriosis on Mitochondrial Function and Development of Early Mouse Embryos 2013
- Pelvic endometriosis with peritoneal fluid reduces pregnancy rates in women undergoing intrauterine insemination 2013
- The Expression and Functionality of Transient Receptor Potential Vanilloid 1 in Ovarian Endometriomas 2012
- Endometriosis and Oxidative Stress 2012
- Female Infertility and Antioxidants 2010
- Mediadores inflamatórios na dor pélvica crônica identificação de possíveis marcadores séricos da doença 2010
- Dietary therapy: a new strategy for management of chronic pelvic pain 2010
- SIGNIFICANCE OF OXIDATIVE STRESS IN HUMAN REPRODUCTION 2009
- The endothelial nitric oxide synthase Glu298Asp polymorphism is not a risk factor for endometriosis in south Indian women 2008
- Pathogenic mechanisms in endometriosis-associated infertility 2008
- Role of oxidative stress in endometriosis 2006
- Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis 2003
- The Glu298→Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis 2003
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