Endometriosis: A new perspective on epigenetics and oxidative stress

Yu Guan; Guan Y; Yawen Chen; Chen Y; Ya‐Wen Chen; Lin R; Rong Lin; Tinghui Mo; Mo T; Shiyu Li; Yiran Li; Li S; Cao Y; Ying Cao; Yin T; Tailang Yin; Lianghui Diao; Yuye Li; Li Y

doi:10.1016/j.jri.2025.104462

Endometriosis: A new perspective on epigenetics and oxidative stress

Yu Guan, Guan Y, Yawen Chen, Chen Y, Ya‐Wen Chen, Lin R, Rong Lin, Tinghui Mo, Mo T, Shiyu Li, Yiran Li, Li S, Cao Y, Ying Cao, Yin T, Tailang Yin, Lianghui Diao, Yuye Li, Li Y

Journal of reproductive immunology · 2025 · vol. 169 , pp. 104462 · doi:10.1016/j.jri.2025.104462 · PMID:40010026 · W4407836082

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the relationship between epigenetics and oxidative stress as a new perspective on understanding endometriosis.

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Abstract

As a complex chronic gynecological disorder characterized by multifaceted etiology involving genetics, environment, immunity and inflammation, endometriosis (EM) has long been a significant concern for women of reproductive age worldwide. This review aimed to comprehensively examine the interplay between epigenetics and oxidative stress (OS) in the pathogenesis of EM. Through the integration of cutting-edge research, the response of OS signals to epigenetic modifications was explored. The microbiome exerts an influence on this causal regulatory relationship, and these mechanisms collectively contribute to the pathophysiology of EM. Specifically, this article highlighted the roles of epigenetics and OS in EM and underscored the importance of the microbiome as a regulatory link. A discussion was also held on the future directions of biomarkers and precision medicine, including the application prospects of epigenetic and OS markers in the diagnosis and treatment decision-making of EM, and innovations in therapeutic strategies like targeting epigenetic modifications and antioxidant therapies. Moreover, this review emphasized the potential of multi-omics integrated analysis to deepen the understanding of the disease, guide future therapeutic strategies and promote personalized medicine.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (3)

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