Endometriosis: A new perspective on epigenetics and oxidative stress

Yu Guan; Yawen Chen; Ya‐Wen Chen; Rong Lin; Tinghui Mo; Shiyu Li; Yiran Li; Ying Cao; Tailang Yin; Lianghui Diao; Yuye Li

doi:10.1016/j.jri.2025.104462

Endometriosis: A new perspective on epigenetics and oxidative stress

Yu Guan, Yawen Chen, Ya‐Wen Chen, Rong Lin, Tinghui Mo, Shiyu Li, Yiran Li, Ying Cao, Tailang Yin, Lianghui Diao, Yuye Li

Journal of reproductive immunology · 2025 · vol. 169 , pp. 104462 · doi:10.1016/j.jri.2025.104462 · PMID:40010026 · W4407836082

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the relationship between epigenetics and oxidative stress as a new perspective on understanding endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic Epigenesis, Genetic

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References (100)

Cited by (2)

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[1] Aberrant histone modification in endometriosis via openalex

[2] Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis via openalex

[3] Accurate diagnosis of endometriosis using serum microRNAs via openalex

[4] An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review via openalex

[5] Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota via openalex

[6] Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis via openalex

[7] A potential link of oxidative stress and cell cycle regulation for development of endometriosis via openalex

[8] Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target via openalex

[9] Bacterial contamination hypothesis: a new concept in endometriosis via openalex

[10] Bacterial infection in endometriosis: a silver-lining for the development of new non-hormonal therapy? via openalex

[11] CCAAT/Enhancer-Binding Protein α Is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis via openalex

[12] Challenges in endometriosis miRNA studies — From tissue heterogeneity to disease specific miRNAs via openalex

[13] Changing the “scope” of diagnosing endometriosis: the new frontier of noninvasive markers via openalex

[14] Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise via openalex

[15] Commonalities and Disparities between Endometriosis and Chronic Endometritis: Therapeutic Potential of Novel Antibiotic Treatment Strategy against Ectopic Endometrium via openalex

[16] COX-2 gene promoter DNA methylation status in eutopic and ectopic endometrium of Egyptian women with endometriosis via openalex

[17] Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature via openalex

[18] Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis via openalex

[19] Demethylation of a nonpromoter cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant up-regulation in endometriotic tissues via openalex

[20] Effects of endometriosis on immunity and mucosal microbial community dynamics in female olive baboons via openalex

[21] Endometriosis via openalex

[22] Endometriosis via openalex

[23] Endometriosis and dysbiosis: State of art via openalex

[24] Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics via openalex

[25] Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility via openalex

[26] Epigenetic regulation of the pathological process in endometriosis via openalex

[27] Epigenetics, endometriosis and sex steroid receptors: An update on the epigenetic regulatory mechanisms of estrogen and progesterone receptors in patients with endometriosis via openalex

[28] Epigenetics of Estrogen and Progesterone Receptors in Endometriosis via openalex

[29] Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis via openalex

[30] Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis via openalex

[31] Evidence in Support for the Progressive Nature of Ovarian Endometriomas via openalex

[32] Experimental Murine Endometriosis Induces DNA Methylation and Altered Gene Expression in Eutopic Endometrium1 via openalex

[33] Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review via openalex

[34] GATA6 expression promoted by an active enhancer may become a molecular marker in endometriosis lesions via openalex

[35] Genome-Wide DNA Methylation Profiling in Cultured Eutopic and Ectopic Endometrial Stromal Cells via openalex

[36] Gut Microbiota Exceeds Cervical Microbiota for Early Diagnosis of Endometriosis via openalex

[37] Heritable aspects of endometriosis via openalex

[38] Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link via openalex

[39] Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells via openalex

[40] IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis via openalex

[41] Impact of nerve‐sparing posterolateral parametrial excision for deep infiltrating endometriosis on postoperative bowel, urinary, and sexual function via openalex

[42] Independent Replication and Meta-Analysis for Endometriosis Risk Loci via openalex

[43] Intricate Connections between the Microbiota and Endometriosis via openalex

[44] Magnetic resonance imaging to assess familial risk in relatives of women with endometriosis via openalex

[45] Methylation analysis of HOXA10 regulatory elements in patients with endometriosis via openalex

[46] MicroRNA 135 Regulates HOXA10 Expression in Endometriosis via openalex

[47] MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis via openalex

[48] MicroRNAs and Endometriosis: Distinguishing Drivers from Passengers in Disease Pathogenesis via openalex

[49] MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance via openalex

[50] MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1 via openalex

[51] miR‑455 targets FABP4 to protect human endometrial stromal cells from cytotoxicity induced by hydrogen peroxide via openalex

[52] Oxidative Imbalance in Endometriosis-Related Infertility—The Therapeutic Role of Antioxidants via openalex

[53] Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation via openalex

[54] Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility via openalex

[55] Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis via openalex

[56] Oxidative stress‐related effects on various aspects of endometriosis via openalex

[57] Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis. via openalex

[58] Pathogenesis Based Diagnosis and Treatment of Endometriosis via openalex

[59] Pathogenesis of endometriosis: the genetic/epigenetic theory via openalex

[60] Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation (Review) via openalex

[61] Pathophysiology, diagnosis, and management of endometriosis via openalex

[62] Prevalence of high‐risk human papillomavirus infection in women with ovarian endometriosis via openalex

[63] Progesterone resistance in endometriosis: origins, consequences and interventions via openalex

[64] Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Adenomyosis and Its Rectification by a Histone Deacetylase Inhibitor and a Demethylation Agent via openalex

[65] Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Endometriosis via openalex

[66] Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1 via openalex

[67] Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex

[68] Protein oxidative stress markers in peritoneal fluids of women with deep infiltrating endometriosis are increased via openalex

[69] Reactive Oxygen Species Controls Endometriosis Progression via openalex

[70] Redox regulation of microRNAs in endometriosis-associated pain via openalex

[71] Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis via openalex

[72] Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway via openalex

[73] Robotic assisted versus laparoscopic surgery for deep endometriosis: a meta-analysis of current evidence via openalex

[74] Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model via openalex

[75] Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies† via openalex

[76] Selective inhibition of prostaglandin E2 receptors EP2 and EP4 modulates DNA methylation and histone modification machinery proteins in human endometriotic cells via openalex

[77] Suppression of COUP-TFII by Proinflammatory Cytokines Contributes to the Pathogenesis of Endometriosis via openalex

[78] Targeting Oxidative Stress Involved in Endometriosis and Its Pain via openalex

[79] Targeting oxidative stress to treat endometriosis via openalex

[80] The bidirectional relationship between endometriosis and microbiome via openalex

[81] The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial via openalex

[82] The Essential Role of GATA6 in the Activation of Estrogen Synthesis in Endometriosis via openalex

[83] The Origin and Pathogenesis of Endometriosis via openalex

[84] The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex

[85] Therapeutic effects of Huayu Jiedu formula on endometriosis via downregulating GATA 6 expression via openalex

[86] The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression via openalex

[87] The severity and frequency distribution of endometriosis subtypes at different ages: a model to understand the natural history of endometriosis based on single centre/single surgeon data via openalex

[88] Transcriptional Activation of Steroidogenic Factor-1 by Hypomethylation of the 5′ CpG Island in Endometriosis via openalex

[89] Update on endometriosis pathogenesis via openalex

[90] W3165294846 via openalex

[91] W2753407840 via openalex

[92] W3165519339 via openalex

[93] W2617005810 via openalex

[94] W3174749050 via openalex

[95] W3200495353 via openalex

[96] W2609484747 via openalex

[97] W2546611209 via openalex

[98] W4205949673 via openalex

[99] W2472118218 via openalex

[100] W2188590881 via openalex