Autoimmune response in women with endometriosis

A Iborra, Antoni Iborra, Iborra A, J. Palacio, J R Palacio, Palacio JR, Z Ulcova-Gallova, Ulcova-Gallova Z, Z Ulčová-Gallová, P Martínez, P. Martı́nez
American journal of reproductive immunology (New York, N.Y. : 1989) · 2000 · vol. 44(4) , pp. 236–241 · doi:10.1111/j.8755-8920.2000.440408.x · PMID:11076096 · W2001445914
Observational OA: bronze CC0 ⤵ 29 in-corpus citations
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This study found that the severity of endometriosis correlates with increased anti-endometrial antibodies (AEA) in serum, with lower rates of anti-sperm and anti-zona pellucida antibodies also observed in affected women.

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Abstract

PROBLEM: The aim of this study was to investigate the humoral immune response to the female reproductive tissues associated with endometriosis (grades I-III) (n = 52), compared with a group of healthy fertile women (n = 6). METHOD OF STUDY: An ELISA with cultured endometrial cell lines in monolayer was used to determine the presence of anti-endometrial antibodies (AEA). For anti-zona pellucida antibodies (AZPA) assessment a conventional ELISA was employed. The presence of antibodies to human sperm (ASA) was performed by the tray agglutination test (TAT). RESULTS: Endometriosis grade III was associated with AEA in serum in the 45.4% of patients. The presence of AEA in serum is correlated to endometriosis severity. The 8.7% of women with endometriosis showed ASA, and the 10.9% of them were positive for AZPA. Antibodies specific for endometrial cells do not show reaction to any gamete antigen (sperm or oocyte), suggesting that they are not cross reactive. CONCLUSIONS: Severity of endometriosis is correlated with high titers of AEA.

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Condition tags

endometriosis

MeSH descriptors

Autoimmunity Autoimmunity Endometriosis Adult Adult Agglutination Tests Agglutination Tests Antibodies Antibodies Antibodies Antibodies Ascitic Fluid Ascitic Fluid Ascitic Fluid Autoantibodies Autoantibodies Autoantibodies Autoantibodies Case-Control Studies Case-Control Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (27)

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