Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

Hong‐Nerng Ho, H N Ho, Wu MY, M Y Wu, Ming‐Yih Wu, K H Chao, Chao KH, Kuang‐Han Chao, C D Chen, Chen CD, Chin‐Der Chen, Shee‐Uan Chen, S U Chen, Chen Su, Hsin‐Fu Chen, H F Chen, Chen HF, Yang YS, Y S Yang, Yu‐Shih Yang
American journal of obstetrics and gynecology · 1996 · vol. 175(5) , pp. 1236–1241 · doi:10.1016/s0002-9378(96)70034-0 · PMID:8942494 · W2082748702
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This study found reduced interferon gamma production and impaired T-lymphocyte proliferation in the peritoneal fluid of women diagnosed with endometriosis.

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Abstract

OBJECTIVE: Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. STUDY DESIGN: Concentrations of peritoneal cytokines, including interleukin-1 beta, interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-alpha were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. RESULTS: A significant increase in peritoneal interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. CONCLUSION: These results indicate that regional immunologic dysfunction might be invoked in the disease process of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Interferon-gamma Lymphocyte Activation Lymphocyte Activation T-Lymphocytes Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Female Female Humans Humans Interferon-gamma Interferon-gamma Leuprolide Leuprolide Leuprolide T-Lymphocytes

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (50)

Source provenance

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