Designing a Pragmatic Dose-Escalation for Vitamin-D to Reduce Endometriosis Related Pain after Laparoscopy in Vitamin- D Deficient Women

Aml El-Shabrawy
In: clinics in Mother and Child Health · 2021 · pp. 1–6 · doi:10.35248/2090-7214.21.s8.002 · W3200244838
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This study investigated the effectiveness of escalating vitamin D doses in reducing endometriosis pain after surgery in deficient women, finding no significant difference in pain scores compared to placebo.

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Abstract

Objective: the study aimed to discover the subjective cure rate, and the safety of using escalating dose regimens of solubilized cholecalciferol in the medical treatment of endometriosis- related pain after ablative surgeries in vitamin-D deficient women. Design classification: Prospective study. Setting: Alsaedy Maternity Hospital, Makka, Saudi Arabia. Patients and interventions: In this double-blind clinical trial, we enlisted patients with endometriosis assessed for dysmenorrhea and pelvic discomfort by VAS test at 8 weeks after treatment by laparoscopy. All patients were vitamin-D deficient (<12 ng/ml). They were arbitrarily received vitamin-D (50 000 IU weekly for 6 months) or placebo. Intensity of pain in the 2 groups was reassessed at 6 months after surgery. Results: There were 25 patients in the vitamin-D group and 25 in the placebo group. Standard features in both groups were analogous. Subsequent to the administration of vitamin-D or placebo, we did not find significant differences in severity of pelvic pain score (p=0.09) and dysmenorrhea score (p=0.366) between the 2 groups. Mean pelvic pain score at 6 months after laparoscopy in the vitamin-D group was 2.96 ± 2 and in placebo group it was 3.3 ± 2 (p=0.55). Mean dysmenorrhea score was 2.44 ± 1.5 in the vitamin-D group and 2.5 ± 1.3 in the placebo group (p=0.88). Conclusion: After ablative surgery for endometriosis, vitamin-D treatment did not have a noteworthy outcome in decreasing dysmenorrhea and/or pelvic pain.

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Outcome instruments

VAS-pain

Condition tags

endometriosisdysmenorrhea

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