Designing a Pragmatic Dose-Escalation for Vitamin-D to Reduce Endometriosis Related Pain after Laparoscopy in Vitamin- D Deficient Women

Aml El-Shabrawy
In: clinics in Mother and Child Health · 2021 · pp. 1–6 · doi:10.35248/2090-7214.21.s8.002 · W3200244838
OA: closed CC0
View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study investigated the effectiveness of escalating vitamin D doses in reducing endometriosis pain after surgery in deficient women, finding no significant difference in pain scores compared to placebo.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objective: the study aimed to discover the subjective cure rate, and the safety of using escalating dose regimens of solubilized cholecalciferol in the medical treatment of endometriosis- related pain after ablative surgeries in vitamin-D deficient women. Design classification: Prospective study. Setting: Alsaedy Maternity Hospital, Makka, Saudi Arabia. Patients and interventions: In this double-blind clinical trial, we enlisted patients with endometriosis assessed for dysmenorrhea and pelvic discomfort by VAS test at 8 weeks after treatment by laparoscopy. All patients were vitamin-D deficient (<12 ng/ml). They were arbitrarily received vitamin-D (50 000 IU weekly for 6 months) or placebo. Intensity of pain in the 2 groups was reassessed at 6 months after surgery. Results: There were 25 patients in the vitamin-D group and 25 in the placebo group. Standard features in both groups were analogous. Subsequent to the administration of vitamin-D or placebo, we did not find significant differences in severity of pelvic pain score (p=0.09) and dysmenorrhea score (p=0.366) between the 2 groups. Mean pelvic pain score at 6 months after laparoscopy in the vitamin-D group was 2.96 ± 2 and in placebo group it was 3.3 ± 2 (p=0.55). Mean dysmenorrhea score was 2.44 ± 1.5 in the vitamin-D group and 2.5 ± 1.3 in the placebo group (p=0.88). Conclusion: After ablative surgery for endometriosis, vitamin-D treatment did not have a noteworthy outcome in decreasing dysmenorrhea and/or pelvic pain.

My notes (saved in your browser only)

Outcome instruments

VAS-pain

Condition tags

endometriosisdysmenorrhea

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK