Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis

Daniela Roxana Matasariu, Cristina-Elena Mandici, Alexandra Ursache, Alexandra Irma Gabriela Bauşic, Iuliana Elena Bujor, Alexandra Elena Cristofor, Elvira Brătilă, Ludmila Lozneanu
2023 · doi:10.20944/preprints202306.0322.v1 · W4379381074
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated phosphohistone H3 (PHH3) and vitamin D receptor (VDR) expression in endometriosis tissue, finding PHH3 and VDR positively correlated in untreated patients and suggesting their use in risk stratification.

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Abstract

(1) Background: To investigate the effect of phosphohistone H3 (PHH3) and vitamin D receptor (VDR) in the risk assessment of endometriosis, in two cohorts of women with this pathology, those receiving hormonal treatment, and those without treatment; (2) Methods: In 60 cases of women with endometriosis, the paraffin-embedded endometriosis tissue samples, retrieved after surgery, were immunohistochemically (IHC) analyzed aiming to determine the expression status of PHH3 and VDR; (3) Results: The IHC positive index of PHH3 and VDR of these two groups were compared. PHH3 levels were positively correlated with vitamin D levels, both being increased in patients without treatment. Within the group without treatment, PHH3 and VDR expressions were positively associated; (4) Conclusions: IHC analysis of PHH3 and VDR can be used as an additional tool for risk stratification and prognostic assessment in patients with endometriosis.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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