Nuclear Expression of Phosphohistone H3 and Vitamin D Receptor – New Potential Markers in Diagnosis and Treatment of Endometriosis

Daniela Roxana Matasariu, Matasariu DR, Cristina-Elena Mandici, Mandici C, Ursache A, Alexandra Ursache, Bausic AIG, Alexandra Irma Gabriela Bauşic, Bujor IE, Iuliana Elena Bujor, Cristofor AE, Alexandra Elena Cristofor, Elvira Brătilă, Lozneanu L, Ludmila Lozneanu
2023 · doi:10.20944/preprints202306.0322.v1 · W4379381074
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated phosphohistone H3 (PHH3) and vitamin D receptor (VDR) expression in endometriosis tissue, finding PHH3 and VDR positively correlated in untreated patients and suggesting their use in risk stratification.

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Abstract

(1) Background: To investigate the effect of phosphohistone H3 (PHH3) and vitamin D receptor (VDR) in the risk assessment of endometriosis, in two cohorts of women with this pathology, those receiving hormonal treatment, and those without treatment; (2) Methods: In 60 cases of women with endometriosis, the paraffin-embedded endometriosis tissue samples, retrieved after surgery, were immunohistochemically (IHC) analyzed aiming to determine the expression status of PHH3 and VDR; (3) Results: The IHC positive index of PHH3 and VDR of these two groups were compared. PHH3 levels were positively correlated with vitamin D levels, both being increased in patients without treatment. Within the group without treatment, PHH3 and VDR expressions were positively associated; (4) Conclusions: IHC analysis of PHH3 and VDR can be used as an additional tool for risk stratification and prognostic assessment in patients with endometriosis.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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